Sensors 2013, 13(4), 5130-5166; doi:10.3390/s130405130
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Targeting agr- and agr-Like Quorum Sensing Systems for Development of Common Therapeutics to Treat Multiple Gram-Positive Bacterial Infections

1,2,* email, 1,2email and 2,3email
Received: 27 February 2013; in revised form: 6 April 2013 / Accepted: 12 April 2013 / Published: 18 April 2013
(This article belongs to the Section Biosensors)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Invasive infection by the Gram-positive pathogen Staphylococcus aureus is controlled by a four gene operon, agr that encodes a quorum sensing system for the regulation of virulence. While agr has been well studied in S. aureus, the contribution of agr homologues and analogues in other Gram-positive pathogens is just beginning to be understood. Intriguingly, other significant human pathogens, including Clostridium perfringens, Listeria monocytogenes, and Enterococcus faecalis contain agr or analogues linked to virulence. Moreover, other significant human Gram-positive pathogens use peptide based quorum sensing systems to establish or maintain infection. The potential for commonality in aspects of these signaling systems across different species raises the prospect of identifying therapeutics that could target multiple pathogens. Here, we review the status of research into these agr homologues, analogues, and other peptide based quorum sensing systems in Gram-positive pathogens as well as the potential for identifying common pathways and signaling mechanisms for therapeutic discovery.
Keywords: quorum sensing; peptide pheromones; bacterial pathogenesis
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MDPI and ACS Style

Gray, B.; Hall, P.; Gresham, H. Targeting agr- and agr-Like Quorum Sensing Systems for Development of Common Therapeutics to Treat Multiple Gram-Positive Bacterial Infections. Sensors 2013, 13, 5130-5166.

AMA Style

Gray B, Hall P, Gresham H. Targeting agr- and agr-Like Quorum Sensing Systems for Development of Common Therapeutics to Treat Multiple Gram-Positive Bacterial Infections. Sensors. 2013; 13(4):5130-5166.

Chicago/Turabian Style

Gray, Brian; Hall, Pamela; Gresham, Hattie. 2013. "Targeting agr- and agr-Like Quorum Sensing Systems for Development of Common Therapeutics to Treat Multiple Gram-Positive Bacterial Infections." Sensors 13, no. 4: 5130-5166.

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