Sensors 2013, 13(11), 15422-15433; doi:10.3390/s131115422

Genetically Encoded Fluorescent Redox Probes

Department of Chemistry, University of California, 501 Big Springs Road, Riverside, CA 92521, USA
* Author to whom correspondence should be addressed.
Received: 19 October 2013; in revised form: 2 November 2013 / Accepted: 5 November 2013 / Published: 11 November 2013
(This article belongs to the Special Issue Fluorescent Biosensors)
PDF Full-text Download PDF Full-Text [593 KB, uploaded 11 November 2013 13:34 CET]
Abstract: Redox processes are involved in almost every cell of the body as a consequence of aerobic life. In the past decades, redox biology has been increasingly recognized as one of the key themes in cell signaling. The progress has been accelerated by development of fluorescent probes that can monitor redox conditions and dynamics in cells and cell compartments. This short paper focuses on fluorescent redox probes that are genetically encoded, and discusses their properties, molecular mechanism, advantages and pitfalls. Our recent work on reaction-based encoded probes that are responsive to particular redox signaling molecules is also reviewed. Future challenges and directions are also commented.
Keywords: redox signaling; fluorescent protein (FP)-based sensors; reaction-based probes; unnatural amino acids (UAAs); redox probes

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Ren, W.; Ai, H.-W. Genetically Encoded Fluorescent Redox Probes. Sensors 2013, 13, 15422-15433.

AMA Style

Ren W, Ai H-W. Genetically Encoded Fluorescent Redox Probes. Sensors. 2013; 13(11):15422-15433.

Chicago/Turabian Style

Ren, Wei; Ai, Hui-Wang. 2013. "Genetically Encoded Fluorescent Redox Probes." Sensors 13, no. 11: 15422-15433.

Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert