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Sensors 2012, 12(7), 9467-9475; doi:10.3390/s120709467

A Portable and Power-Free Microfluidic Device for Rapid and Sensitive Lead (Pb2+) Detection

1,*  and 2,*
1 Laboratory of Advanced Materials, Fudan University, 2205 Songhu Road, Shanghai 200438, China 2 Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China 3 Shanghai Institute of Measurement and Testing Technology, Shanghai 201203, China
* Authors to whom correspondence should be addressed.
Received: 29 May 2012 / Revised: 6 June 2012 / Accepted: 2 July 2012 / Published: 10 July 2012
(This article belongs to the Section Biosensors)
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A portable and power-free microfluidic device was designed for rapid and sensitive detection of lead (Pb2+). 11-mercaptoundecanoic acid (MUA)-functionalized gold nanoparticles (MUA-AuNPs) aggregated in the presence of Pb2+ for the chelation mechanism. When we performed this analysis on a polydimethylsiloxane (PDMS) microfluidic chip, the aggregations deposited onto the surface of chip and formed dark lines along the laminar flows in the zigzag microchannels. This visual result can be observed by the naked eye through a microscope or just a drop of water as a magnifier. Ten μM Pb2+ was successfully detected.
Keywords: gold nanoparticles; Pb2+; 11-mercaptoundecanoic acid; microfluidic chip gold nanoparticles; Pb2+; 11-mercaptoundecanoic acid; microfluidic chip
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fan, C.; He, S.; Liu, G.; Wang, L.; Song, S. A Portable and Power-Free Microfluidic Device for Rapid and Sensitive Lead (Pb2+) Detection. Sensors 2012, 12, 9467-9475.

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