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Sensors 2012, 12(6), 8319-8337; doi:10.3390/s120608319

Diagnostic Devices for Isothermal Nucleic Acid Amplification

Institute of Biomedical Engineering, National Taiwan University, Taipei 10617, Taiwan
Institute of Biomedical Electronic and Bioinformatics, National Taiwan University, Taipei 10617, Taiwan
Center for Emerging Material and Advanced Devices, National Taiwan University, Taipei 10617, Taiwan
Author to whom correspondence should be addressed.
Received: 2 May 2012 / Revised: 29 May 2012 / Accepted: 7 June 2012 / Published: 14 June 2012
(This article belongs to the Special Issue Biomarkers and Nanosensors: New Approaches for Biology and Medicine)
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Since the development of the polymerase chain reaction (PCR) technique, genomic information has been retrievable from lesser amounts of DNA than previously possible. PCR-based amplifications require high-precision instruments to perform temperature cycling reactions; further, they are cumbersome for routine clinical use. However, the use of isothermal approaches can eliminate many complications associated with thermocycling. The application of diagnostic devices for isothermal DNA amplification has recently been studied extensively. In this paper, we describe the basic concepts of several isothermal amplification approaches and review recent progress in diagnostic device development. View Full-Text
Keywords: isothermal nucleic acid amplification; NASBA; SDA; RCA; LAMP; HDA isothermal nucleic acid amplification; NASBA; SDA; RCA; LAMP; HDA

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Chang, C.-C.; Chen, C.-C.; Wei, S.-C.; Lu, H.-H.; Liang, Y.-H.; Lin, C.-W. Diagnostic Devices for Isothermal Nucleic Acid Amplification. Sensors 2012, 12, 8319-8337.

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