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Sensors 2012, 12(5), 5432-5444; doi:10.3390/s120505432
Review

Classifying the Topology of AHL-Driven Quorum Sensing Circuits in Proteobacterial Genomes

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Received: 1 February 2012; in revised form: 24 March 2012 / Accepted: 26 April 2012 / Published: 27 April 2012
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Abstract: Virulence and adaptability of many Gram-negative bacterial species are associated with an N-acylhomoserine lactone (AHL) gene regulation mechanism called quorum sensing (QS). The arrangement of quorum sensing genes is variable throughout bacterial genomes, although there are unifying themes that are common among the various topological arrangements. A bioinformatics survey of 1,403 complete bacterial genomes revealed characteristic gene topologies in 152 genomes that could be classified into 16 topological groups. We developed a concise notation for the patterns and show that the sequences of LuxR regulators and LuxI autoinducer synthase proteins cluster according to the topological patterns. The annotated topologies are deposited online with links to sequences and genome annotations at http://bacteria.itk.ppke.hu/QStopologies/.
Keywords: quorum sensing; N-AHL; topology; proteobacteria; bacteria quorum sensing; N-AHL; topology; proteobacteria; bacteria
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Gelencsér, Z.; Choudhary, K.S.; Coutinho, B.G.; Hudaiberdiev, S.; Galbáts, B.; Venturi, V.; Pongor, S. Classifying the Topology of AHL-Driven Quorum Sensing Circuits in Proteobacterial Genomes. Sensors 2012, 12, 5432-5444.

AMA Style

Gelencsér Z, Choudhary KS, Coutinho BG, Hudaiberdiev S, Galbáts B, Venturi V, Pongor S. Classifying the Topology of AHL-Driven Quorum Sensing Circuits in Proteobacterial Genomes. Sensors. 2012; 12(5):5432-5444.

Chicago/Turabian Style

Gelencsér, Zsolt; Choudhary, Kumari Sonal; Coutinho, Bruna Goncalves; Hudaiberdiev, Sanjarbek; Galbáts, Borisz; Venturi, Vittorio; Pongor, Sándor. 2012. "Classifying the Topology of AHL-Driven Quorum Sensing Circuits in Proteobacterial Genomes." Sensors 12, no. 5: 5432-5444.


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