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Sensors 2012, 12(5), 5432-5444; doi:10.3390/s120505432

Classifying the Topology of AHL-Driven Quorum Sensing Circuits in Proteobacterial Genomes

2,*  and 2,*
1 Faculty of Information Technology, PázmányPéter Catholic University, Práter u. 50/a, Budapest 1083, Hungary 2 International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, Trieste 32149, Italy 3 The Capes Foundation, Ministry of Education of Brazil, Cx postal 250, Brasilia, DF 70.040-020, Brazil 4 Biological Research Center, Temesvári krt 62, Szeged 6726, Hungary
* Authors to whom correspondence should be addressed.
Received: 1 February 2012 / Revised: 24 March 2012 / Accepted: 26 April 2012 / Published: 27 April 2012


Virulence and adaptability of many Gram-negative bacterial species are associated with an N-acylhomoserine lactone (AHL) gene regulation mechanism called quorum sensing (QS). The arrangement of quorum sensing genes is variable throughout bacterial genomes, although there are unifying themes that are common among the various topological arrangements. A bioinformatics survey of 1,403 complete bacterial genomes revealed characteristic gene topologies in 152 genomes that could be classified into 16 topological groups. We developed a concise notation for the patterns and show that the sequences of LuxR regulators and LuxI autoinducer synthase proteins cluster according to the topological patterns. The annotated topologies are deposited online with links to sequences and genome annotations at
Keywords: quorum sensing; N-AHL; topology; proteobacteria; bacteria quorum sensing; N-AHL; topology; proteobacteria; bacteria
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Gelencsér, Z.; Choudhary, K.S.; Coutinho, B.G.; Hudaiberdiev, S.; Galbáts, B.; Venturi, V.; Pongor, S. Classifying the Topology of AHL-Driven Quorum Sensing Circuits in Proteobacterial Genomes. Sensors 2012, 12, 5432-5444.

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