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Prototypes of Newly Conceived Inorganic and Biological Sensors for Health and Environmental Applications
Laboratories of Biophysics and Nanobiotechnology, Department of Experimental Medicine (DIMES), University of Genoa, Genoa 16132, Italy
Nanoworld Institute Fondazione EL.B.A. Nicolini, Bergamo 24100, Italy
Elbatech Srl, Marciana, Marciana 57030, Italy
* Author to whom correspondence should be addressed.
Received: 8 October 2012; in revised form: 7 December 2012 / Accepted: 11 December 2012 / Published: 12 December 2012
Abstract: This paper describes the optimal implementation of three newly conceived sensors for both health and environmental applications, utilizing a wide range of detection methods and complex nanocomposites. The first one is inorganic and based on matrices of calcium oxide, the second is based on protein arrays and a third one is based on Langmuir-Blodgett laccase multi-layers. Special attention was paid to detecting substances significant to the environment (such as carbon dioxide) and medicine (drug administration, cancer diagnosis and prognosis) by means of amperometric, quartz crystal microbalance with frequency (QCM_F) and quartz crystal microbalance with dissipation monitoring (QCM_D) technologies. The resulting three implemented nanosensors are described here along with proofs of principle and their corresponding applications.
Keywords: QCM_D; protein-protein interaction; calcium oxide matrices; CO2; Langmuir-Blodgett; laccase; amperometry; clomipramine
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Nicolini, C.; Adami, M.; Sartore, M.; Bragazzi, N.L.; Bavastrello, V.; Spera, R.; Pechkova, E. Prototypes of Newly Conceived Inorganic and Biological Sensors for Health and Environmental Applications. Sensors 2012, 12, 17112-17127.
Nicolini C, Adami M, Sartore M, Bragazzi NL, Bavastrello V, Spera R, Pechkova E. Prototypes of Newly Conceived Inorganic and Biological Sensors for Health and Environmental Applications. Sensors. 2012; 12(12):17112-17127.
Nicolini, Claudio; Adami, Manuela; Sartore, Marco; Bragazzi, Nicola L.; Bavastrello, Valter; Spera, Rosanna; Pechkova, Eugenia. 2012. "Prototypes of Newly Conceived Inorganic and Biological Sensors for Health and Environmental Applications." Sensors 12, no. 12: 17112-17127.