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Sensors 2010, 10(9), 8398-8410; doi:10.3390/s100908398
Article

A Novel Electrochemical Sensor for Probing Doxepin Created on a Glassy Carbon Electrode Modified with Poly(4-Amino- benzoic Acid)/Multi-Walled Carbon Nanotubes Composite Film

,
,
, *  and *
Department of Chemistry & Center of Analysis and Measurement, Fudan University, Handan Road 220#, Shanghai 200433, China
* Authors to whom correspondence should be addressed.
Received: 7 July 2010 / Revised: 31 July 2010 / Accepted: 7 September 2010 / Published: 8 September 2010
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Abstract

A novel electrochemical sensor for sensitive detection of doxepin was prepared, which was based on a glassy carbon electrode modified with poly(4-aminobenzoic acid)/multi-walled carbon nanotubes composite film [poly(4-ABA)/MWNTs/GCE]. The sensor was characterized by scanning electron microscopy and electrochemical methods. It was observed that poly(4-ABA)/MWNTs/GCE showed excellent preconcentration function and electrocatalytic activities towards doxepin. Under the selected conditions, the anodic peak current was linear to the logarithm of doxepin concentration in the range from 1.0 ´ 10−9 to 1.0 ´ 10−6 M, and the detection limit obtained was 1.0 × 10−10 M. The poly(4-ABA)/MWNTs/GCE was successfully applied in the measurement of doxepin in commercial pharmaceutical formulations, and the analytical accuracy was confirmed by comparison with a conventional ultraviolet spectrophotometry assay.
Keywords: poly(4-aminobenzoic acid); multi-walled carbon nanotubes; nanocomposite; doxepin; detection poly(4-aminobenzoic acid); multi-walled carbon nanotubes; nanocomposite; doxepin; detection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Xu, X.-L.; Huang, F.; Zhou, G.-L.; Zhang, S.; Kong, J.-L. A Novel Electrochemical Sensor for Probing Doxepin Created on a Glassy Carbon Electrode Modified with Poly(4-Amino- benzoic Acid)/Multi-Walled Carbon Nanotubes Composite Film. Sensors 2010, 10, 8398-8410.

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