Next Article in Journal
Novel Ultra-Sensitive Detectors in the 10–50 μm Wavelength Range
Previous Article in Journal
Color Regeneration from Reflective Color Sensor Using an Artificial Intelligent Technique
Article Menu

Export Article

Open AccessArticle
Sensors 2010, 10(9), 8398-8410; doi:10.3390/s100908398

A Novel Electrochemical Sensor for Probing Doxepin Created on a Glassy Carbon Electrode Modified with Poly(4-Amino- benzoic Acid)/Multi-Walled Carbon Nanotubes Composite Film

Department of Chemistry & Center of Analysis and Measurement, Fudan University, Handan Road 220#, Shanghai 200433, China
*
Authors to whom correspondence should be addressed.
Received: 7 July 2010 / Revised: 31 July 2010 / Accepted: 7 September 2010 / Published: 8 September 2010
View Full-Text   |   Download PDF [622 KB, uploaded 21 June 2014]   |  

Abstract

A novel electrochemical sensor for sensitive detection of doxepin was prepared, which was based on a glassy carbon electrode modified with poly(4-aminobenzoic acid)/multi-walled carbon nanotubes composite film [poly(4-ABA)/MWNTs/GCE]. The sensor was characterized by scanning electron microscopy and electrochemical methods. It was observed that poly(4-ABA)/MWNTs/GCE showed excellent preconcentration function and electrocatalytic activities towards doxepin. Under the selected conditions, the anodic peak current was linear to the logarithm of doxepin concentration in the range from 1.0 ´ 10−9 to 1.0 ´ 10−6 M, and the detection limit obtained was 1.0 × 10−10 M. The poly(4-ABA)/MWNTs/GCE was successfully applied in the measurement of doxepin in commercial pharmaceutical formulations, and the analytical accuracy was confirmed by comparison with a conventional ultraviolet spectrophotometry assay.
Keywords: poly(4-aminobenzoic acid); multi-walled carbon nanotubes; nanocomposite; doxepin; detection poly(4-aminobenzoic acid); multi-walled carbon nanotubes; nanocomposite; doxepin; detection
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Xu, X.-L.; Huang, F.; Zhou, G.-L.; Zhang, S.; Kong, J.-L. A Novel Electrochemical Sensor for Probing Doxepin Created on a Glassy Carbon Electrode Modified with Poly(4-Amino- benzoic Acid)/Multi-Walled Carbon Nanotubes Composite Film. Sensors 2010, 10, 8398-8410.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top