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Sensors 2010, 10(5), 5031-5053; doi:10.3390/s100505031
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Transcriptional Regulation of Glucose Sensors in Pancreatic β-Cells and Liver: An Update

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Received: 1 February 2010 / Revised: 7 May 2010 / Accepted: 13 May 2010 / Published: 19 May 2010
(This article belongs to the Section Biosensors)
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Abstract

Pancreatic β-cells and the liver play a key role in glucose homeostasis. After a meal or in a state of hyperglycemia, glucose is transported into the β-cells or hepatocytes where it is metabolized. In the β-cells, glucose is metabolized to increase the ATP:ADP ratio, resulting in the secretion of insulin stored in the vesicle. In the hepatocytes, glucose is metabolized to CO2, fatty acids or stored as glycogen. In these cells, solute carrier family 2 (SLC2A2) and glucokinase play a key role in sensing and uptaking glucose. Dysfunction of these proteins results in the hyperglycemia which is one of the characteristics of type 2 diabetes mellitus (T2DM). Thus, studies on the molecular mechanisms of their transcriptional regulations are important in understanding pathogenesis and combating T2DM. In this paper, we will review a recent update on the progress of gene regulation of glucose sensors in the liver and β-cells.
Keywords: glucose sensor; solute carrier family 2 (SLC2A2); glucokinase (GCK); transcription; liver; pancreatic β-cell glucose sensor; solute carrier family 2 (SLC2A2); glucokinase (GCK); transcription; liver; pancreatic β-cell
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bae, J.-S.; Kim, T.-H.; Kim, M.-Y.; Park, J.-M.; Ahn, Y.-H. Transcriptional Regulation of Glucose Sensors in Pancreatic β-Cells and Liver: An Update. Sensors 2010, 10, 5031-5053.

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