Sensors 2010, 10(5), 5031-5053; doi:10.3390/s100505031
Review

Transcriptional Regulation of Glucose Sensors in Pancreatic β-Cells and Liver: An Update

1,2email, 1,2,3email, 1,2email, 1,2,3email and 1,2,3,* email
Received: 1 February 2010; in revised form: 7 May 2010 / Accepted: 13 May 2010 / Published: 19 May 2010
(This article belongs to the Section Biosensors)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Pancreatic β-cells and the liver play a key role in glucose homeostasis. After a meal or in a state of hyperglycemia, glucose is transported into the β-cells or hepatocytes where it is metabolized. In the β-cells, glucose is metabolized to increase the ATP:ADP ratio, resulting in the secretion of insulin stored in the vesicle. In the hepatocytes, glucose is metabolized to CO2, fatty acids or stored as glycogen. In these cells, solute carrier family 2 (SLC2A2) and glucokinase play a key role in sensing and uptaking glucose. Dysfunction of these proteins results in the hyperglycemia which is one of the characteristics of type 2 diabetes mellitus (T2DM). Thus, studies on the molecular mechanisms of their transcriptional regulations are important in understanding pathogenesis and combating T2DM. In this paper, we will review a recent update on the progress of gene regulation of glucose sensors in the liver and β-cells.
Keywords: glucose sensor; solute carrier family 2 (SLC2A2); glucokinase (GCK); transcription; liver; pancreatic β-cell
PDF Full-text Download PDF Full-Text [709 KB, uploaded 21 June 2014 03:01 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Bae, J.-S.; Kim, T.-H.; Kim, M.-Y.; Park, J.-M.; Ahn, Y.-H. Transcriptional Regulation of Glucose Sensors in Pancreatic β-Cells and Liver: An Update. Sensors 2010, 10, 5031-5053.

AMA Style

Bae J-S, Kim T-H, Kim M-Y, Park J-M, Ahn Y-H. Transcriptional Regulation of Glucose Sensors in Pancreatic β-Cells and Liver: An Update. Sensors. 2010; 10(5):5031-5053.

Chicago/Turabian Style

Bae, Jin-Sik; Kim, Tae-Hyun; Kim, Mi-Young; Park, Joo-Man; Ahn, Yong-Ho. 2010. "Transcriptional Regulation of Glucose Sensors in Pancreatic β-Cells and Liver: An Update." Sensors 10, no. 5: 5031-5053.

Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert