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Sensors 2010, 10(4), 3732-3740; doi:10.3390/s100403732

A Multiwell Electrochemical Biosensor for Real-Time Monitoring of the Behavioural Changes of Cells in Vitro

University Dept Medicine, University of Manchester, MRI, Oxford Rd, Manchester, M13 9WL, UK
Author to whom correspondence should be addressed.
Received: 2 March 2010 / Revised: 1 April 2010 / Accepted: 6 April 2010 / Published: 13 April 2010
(This article belongs to the Special Issue State-of-the-Art Sensors Technology in the UK)
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We report the development of a multiwell biosensor for detecting changes in the electrochemical open circuit potential (OCP) generated by viable human cells in vitro. The instrument features eight culture wells; each containing three gold sensors around a common silver/silver chloride reference electrode, prepared using screen-printed conductive inks. The potential applications of the device were demonstrated by monitoring rheumatoid synovial fibroblasts (RSF) and HepG2 hepatocarcinoma cells in response to chemical and biological treatments. This technology could provide an alternative to conventional end-point assays used in the fields of chemotherapy, toxicology and drug discovery. View Full-Text
Keywords: Oncoprobe; electrochemical; biosensor; HepG2; cycloheximide; camptothecin Oncoprobe; electrochemical; biosensor; HepG2; cycloheximide; camptothecin

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Adlam, D.J.; Woolley, D.E. A Multiwell Electrochemical Biosensor for Real-Time Monitoring of the Behavioural Changes of Cells in Vitro. Sensors 2010, 10, 3732-3740.

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