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Molbank 2018, 2018(2), M989; https://doi.org/10.3390/M989

(Z)-4-[2-(3,4-Difluorophenyl)hydrazono]-3-methyl-1H-pyrazol-5(4H)-one

1
Department of Chemistry, P.A. College of Engineering, Nadupadavu 574153, Mangaluru, Karnataka, India
2
Department of Industrial Chemistry, Mangalore University, Mangalagangothri 574199, Mangaluru, Karnataka, India
3
Department of Studies in Chemistry, Mangalore University, Mangalagangothri 574199, Mangaluru, Karnataka, India
4
Department of Pharmacology and Yenepoya Research Centre, Yenepoya-Deemed to be University, Deralakatte 574153, Mangaluru, Karnataka, India
*
Author to whom correspondence should be addressed.
Received: 24 February 2018 / Revised: 20 March 2018 / Accepted: 29 March 2018 / Published: 31 March 2018
(This article belongs to the Special Issue Heterocycles)
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Abstract

The title compound (Z)-4-[2-(3,4-difluorophenyl)hydrazono]-3-methyl-1H-pyrazol-5(4H)-one 4 was synthesized by the reaction of ethyl 2-[2-(3,4-difluorophenyl)hydrazono]-3-oxobutanoate 3 with hydrazine hydrate. The diazotization of 3,4-difluoroaniline, followed by the treatment with ethyl acetoacetate, afforded intermediate 3. The synthesized compound 4 was characterized by FTIR, 1H-NMR, 13C-NMR and LCMS, and it showed synergistic anti-inflammatory, antiproliferative and antibacterial activities. View Full-Text
Keywords: pyrazol-5(4H)-one; hydrazine hydrate; anti-inflammatory; antiproliferative; antibacterial activity pyrazol-5(4H)-one; hydrazine hydrate; anti-inflammatory; antiproliferative; antibacterial activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mohan, B.J.; Sarojini, B.K.; Narayana, B.; Sindhu Priya, E.S. (Z)-4-[2-(3,4-Difluorophenyl)hydrazono]-3-methyl-1H-pyrazol-5(4H)-one. Molbank 2018, 2018, M989.

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