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Molbank 2018, 2018(2), M1000; https://doi.org/10.3390/M1000

1-[5-(4-Ethoxyphenyl)-3-(naphthalen-1-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one

1
Department of Studies in Chemistry, Mangalore University, Mangalagangothri-574199, Karnataka, India
2
Department of Industrial Chemistry, Mangalore University, Mangalagangothri-574199, Karnataka, India
*
Author to whom correspondence should be addressed.
Received: 23 May 2018 / Revised: 14 June 2018 / Accepted: 17 June 2018 / Published: 19 June 2018
(This article belongs to the Section Organic Synthesis)
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Abstract

The cyclization reaction of 3-(4-ethoxyphenyl)-1-(naphthalen-1-yl)prop-2-en-1-one (1) using hydrazine hydrate in acetic acid medium culminates, resulting in the title compound 1-[5-(4-ethoxyphenyl)-3-(naphthalen-1-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one (2). The structure of the newly synthesized compound is determined by IR, 1H-NMR, 13C-NMR and mass spectral data. In order to evaluate the putative molecular interactions, the title compound (2) is docked against the active site of Cytochrome P450 14α-sterol demethylase (CYP51) from Mycobacterium tuberculosis. View Full-Text
Keywords: pyrazoline; cytochrome P450; molecular docking pyrazoline; cytochrome P450; molecular docking
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Karanth, S.; Narayana, B.; Avvadukkam, J.; Sarojini, B.K. 1-[5-(4-Ethoxyphenyl)-3-(naphthalen-1-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one. Molbank 2018, 2018, M1000.

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