Previous Issue

E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Table of Contents

Molbank, Volume 2018, Issue 2 (June 2018)

  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
  • You may sign up for e-mail alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Readerexternal link to open them.
View options order results:
result details:
Displaying articles 1-4
Export citation of selected articles as:

Research

Jump to: Other

Open AccessCommunication Synthesis of 10-Methoxydiamantan-3-One
Molbank 2018, 2018(2), M990; doi:10.3390/M990
Received: 21 March 2018 / Revised: 1 April 2018 / Accepted: 4 April 2018 / Published: 9 April 2018
PDF Full-text (369 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The synthesis of diamondoids particles up to 1–5 nm, in order to detect the nanostructure in the construction of nanoelectronic devices, for which the present of quantum limitation effects are theoretically presaged, is at the present time problematic. Diamondoids have many important physical
[...] Read more.
The synthesis of diamondoids particles up to 1–5 nm, in order to detect the nanostructure in the construction of nanoelectronic devices, for which the present of quantum limitation effects are theoretically presaged, is at the present time problematic. Diamondoids have many important physical characteristics, including rigidity, lipophilicity, low strain energy, etc. Diamantane and their derivatives are also interesting for the study of nanoparticles. The present study deals with the development of the new synthetic route and diamantine-containing precursor for McMurry coupling reactions. Full article
(This article belongs to the Section Organic Synthesis)
Figures

Scheme 1

Open AccessCommunication 1-[1-(4-Chlorobenzenesulfonyl)-1H-indole-3-yl]-3-[4-(pyridin-2-yl)piperazin-1-yl]propan-1-one
Molbank 2018, 2018(2), M991; doi:10.3390/M991
Received: 17 March 2018 / Revised: 13 April 2018 / Accepted: 16 April 2018 / Published: 18 April 2018
PDF Full-text (2198 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The title compound was prepared by an aza-Michael addition reaction between 1-[1-(4-chlorobenzenesulfonyl)-1H-indole-3-yl]prop-2-en-1-one and 2-piridylpiperazine catalyzed by SiO2. The structural identity of the title compound was proven by elemental analysis and spectroscopic methods (IR, NMR). The compound was assayed in
[...] Read more.
The title compound was prepared by an aza-Michael addition reaction between 1-[1-(4-chlorobenzenesulfonyl)-1H-indole-3-yl]prop-2-en-1-one and 2-piridylpiperazine catalyzed by SiO2. The structural identity of the title compound was proven by elemental analysis and spectroscopic methods (IR, NMR). The compound was assayed in a binding assay at the 5-HT6 receptor, showing poor affinity. Full article
(This article belongs to the Special Issue Heterocycles)
Figures

Other

Jump to: Research

Open AccessShort Note (Z)-4-[2-(3,4-Difluorophenyl)hydrazono]-3-methyl-1H-pyrazol-5(4H)-one
Molbank 2018, 2018(2), M989; doi:10.3390/M989
Received: 24 February 2018 / Revised: 20 March 2018 / Accepted: 29 March 2018 / Published: 31 March 2018
PDF Full-text (2260 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The title compound (Z)-4-[2-(3,4-difluorophenyl)hydrazono]-3-methyl-1H-pyrazol-5(4H)-one 4 was synthesized by the reaction of ethyl 2-[2-(3,4-difluorophenyl)hydrazono]-3-oxobutanoate 3 with hydrazine hydrate. The diazotization of 3,4-difluoroaniline, followed by the treatment with ethyl acetoacetate, afforded intermediate 3. The synthesized compound 4 was
[...] Read more.
The title compound (Z)-4-[2-(3,4-difluorophenyl)hydrazono]-3-methyl-1H-pyrazol-5(4H)-one 4 was synthesized by the reaction of ethyl 2-[2-(3,4-difluorophenyl)hydrazono]-3-oxobutanoate 3 with hydrazine hydrate. The diazotization of 3,4-difluoroaniline, followed by the treatment with ethyl acetoacetate, afforded intermediate 3. The synthesized compound 4 was characterized by FTIR, 1H-NMR, 13C-NMR and LCMS, and it showed synergistic anti-inflammatory, antiproliferative and antibacterial activities. Full article
(This article belongs to the Special Issue Heterocycles)
Figures

Open AccessShort Note 1-Adamantylamidoxime
Molbank 2018, 2018(2), M992; doi:10.3390/M992
Received: 6 April 2018 / Revised: 13 April 2018 / Accepted: 17 April 2018 / Published: 19 April 2018
PDF Full-text (1153 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The title compound was prepared by the nucleophilic addition of hydroxylamine over 1-cyanoadamantane. The poor reactivity of the nitrile substrate, due to its scarcely electrophilic nature, prompted the need to employ several activating conditions. Energy supply via conventional heating, ultrasound, and microwave irradiation
[...] Read more.
The title compound was prepared by the nucleophilic addition of hydroxylamine over 1-cyanoadamantane. The poor reactivity of the nitrile substrate, due to its scarcely electrophilic nature, prompted the need to employ several activating conditions. Energy supply via conventional heating, ultrasound, and microwave irradiation did not lead to product formation. Therefore, Lewis acid catalysis was attempted. Initial tests with ZnCl2 led to product formation in poor yields. Conversely, the use of AlCl3 led to the formation of the desired amidoxime in the moderate yield, which was further increased to an excellent yield by performing the reaction in a more concentrated medium. The structural identity of the title compound was proven by spectroscopic methods (IR, NMR). This compound was later employed as a starting material for the synthesis of 3,5-disubstituted 1,2,4-oxadiazole derivatives as potential 11β-HSD1 inhibitors. Full article
(This article belongs to the Special Issue Molecules from Catalytic Processes)
Figures

Back to Top