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Molbank 2017, 2017(1), M929; doi:10.3390/M929

Oxidative Radical Cyclization–Cyclization Reaction Leading to 1H-Benzo[f]isoindole Derivatives

School of Pharmacy, Hyogo University of Health Sciences, Minatojima, Kobe 650-8530, Japan
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Academic Editor: Norbert Haider
Received: 22 December 2016 / Revised: 25 January 2017 / Accepted: 2 February 2017 / Published: 4 February 2017
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [1948 KB, uploaded 4 February 2017]   |  

Abstract

The synthesis of 1H-benzo[f]isoindole derivatives was achieved by the cascade radical cyclization–cyclization reaction of the active methine substrate having an allyl group and phenyl group as different two radical acceptors. This oxidative transformation proceeded by using iron(III) chloride FeCl3 as a mild oxidant via the intramolecular radical addition to the allyl group followed by the second radical addition to the phenyl group. View Full-Text
Keywords: radical; cyclization; benzoisoindole; iron; oxidation radical; cyclization; benzoisoindole; iron; oxidation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yoshioka, E.; Miyabe, H. Oxidative Radical Cyclization–Cyclization Reaction Leading to 1H-Benzo[f]isoindole Derivatives. Molbank 2017, 2017, M929.

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