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Molbank 2012, 2012(4), M781; doi:10.3390/M781
Short Note

2-[2-(Aziridin-1-yl)ethyl]-5,5-dimethyl-2,5-dihydro-4H-benzo [e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part IV)

*  and
Department of Drug and Natural Product Synthesis, Faculty of Life Sciences, University of Vienna, Althanstra├če 14, A- 1090 Vienna, Austria
* Author to whom correspondence should be addressed.
Received: 27 June 2012 / Accepted: 27 September 2012 / Published: 1 October 2012
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Abstract

An aziridine-containing side chain is attached to an oxonaphthalene-annelated pyrrole in expectation of DNA alkylating properties. The cytotoxicity is evaluated against two cell lines, KB-31 and KB-8511, respectively.
Keywords: pyrrole; DNA-alkylation; anticancer pyrrole; DNA-alkylation; anticancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Spreitzer, H.; Puschmann, C. 2-[2-(Aziridin-1-yl)ethyl]-5,5-dimethyl-2,5-dihydro-4H-benzo [e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part IV). Molbank 2012, 2012, M781.

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