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Molbank 2009, 2009(4), M645; doi:10.3390/M645

Short Note

Methyl 6-Methyl-4-(4-iodophenyl)-1,2,3,4-tetrahydro-2-thioxo-5-pyrimidinecarboxylate

Ning Pan, Wenwen Zhang and Qingjian Liu *

Chemical Engineering and Materials Science, Engineering Research Center of Pesticide and Medicine Intermediate Clean Production, Ministry of Education, College of Chemistry, Shandong Normal University, Jinan 250014, China

* Author to whom correspondence should be addressed.

Received: 23 October 2009 / Accepted: 11 December 2009 / Published: 15 December 2009

Download PDF Full-Text [169 KB, uploaded 15 December 2009 14:50 CET]

Abstract: Methyl 6-methyl-4-(4-iodophenyl)-1,2,3,4-tetrahydro-2-thioxo-5-pyrimidinecarboxylate has been synthesized via Biginelli reaction of 4-iodobenzaldehyde, methyl acetoacetate and thiourea, promoted by microwave irradiation in the presence of iodine under solvent-free conditions in high yield and good purity.

Keywords: Biginelli reaction; solvent-free conditions; microwave irradiation; 3,4-dihydropyrimidin-2(1H)-thione

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  M645.mol 3D structure (MOL, 2 KB) Display in MOL Viewer

  3D structure generated by CORINA by Molecular Networks.

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