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Molbank 2007, 2007(3), M544; doi:10.3390/M544
Short Note

Stereoselective Synthesis of a New cis Monocyclic β-lactam Bearing a Sugar Moiety at Its N1 Position and Its Physical Characterization

1,* , 2 and 1
Received: 29 December 2006 / Accepted: 27 February 2007 / Published: 30 May 2007
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Abstract

Synthesis of a new monocyclic β-lactam containing a sugar moiety at its N1 position via [2+2] cycloaddition reaction of ketene and imine is described. Reaction of achiral phenoxy ketene with chiral aldimine derived from chiral 2, 3, 4, 6-tetra-O-acetyl-β-D-galactopyranosylamine and 2-hydroxy-3-methoxy benzaldehyde resulted in the formation of 2 as a single diastereomer. Then its physical characterization has been determined at the AM1 level of theory.
Keywords: 2-azetidinone; phenoxy ketene; asymmetric synthesis; chiral Schiff bases; sugar; [2+2] cycloaddition 2-azetidinone; phenoxy ketene; asymmetric synthesis; chiral Schiff bases; sugar; [2+2] cycloaddition
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Jarrahpour, A.; Jalbout, A.F.; Alvand, P. Stereoselective Synthesis of a New cis Monocyclic β-lactam Bearing a Sugar Moiety at Its N1 Position and Its Physical Characterization. Molbank 2007, 2007, M544.

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