5,5’-Biindole

doi:10.3390/M474

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Molbank 2006, 2006(2), M474; doi:10.3390/M474

Short Note

5,5’-Biindole

Ramiro Quintanilla-Licea^1,* , Juan F. Colunga-Valladares², Adolfo Caballero-Quintero³, Noemí Waksman³, Ricardo Gomez-Flores¹, Cristina Rodríguez-Padilla¹ and Reyes Tamez-Guerra¹

¹ Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, Pedro de Alba s/n, Cd. Universitaria, San Nicolás de los Garza, Nuevo León, México ² Facultad de Ciencias Químicas, Universidad Autónoma de Nuevo León, Pedro de Alba s/n, Cd. Universitaria, San Nicolás de los Garza, Nuevo León, México ³ Facultad de Medicina, Universidad Autónoma de Nuevo León, Pedro de Alba s/n, Cd. Universitaria, San Nicolás de los Garza, Nuevo León, México

* Author to whom correspondence should be addressed.

Received: 30 January 2006 / Accepted: 9 March 2006 / Published: 10 March 2006

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Abstract: Synthesis of 5,5’-biindole was carried out by the Madelung indole reaction. Under strong basic conditions and high temperatures (350 ºC), N,N’-bis-formyl-o-tolidine underwent cyclization to produce high amounts of the dimeric indole. Full and unambiguous assignments of all 1H- and 13C-NMR resonances of indole and 5,5’-biindole in DMSO-d6 are also reported.

Keywords: Indoloquinolizine; Antitumor activity; Teuber’s reaction; Indole synthesis; 1H-NMR; 13C-NMR

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Cite This Article

MDPI and ACS Style

Quintanilla-Licea, R.; Colunga-Valladares, J.F.; Caballero-Quintero, A.; Waksman, N.; Gomez-Flores, R.; Rodríguez-Padilla, C.; Tamez-Guerra, R. 5,5’-Biindole. Molbank 2006, 2006, M474.

AMA Style

Quintanilla-Licea R., Colunga-Valladares J.F., Caballero-Quintero A., Waksman N., Gomez-Flores R., Rodríguez-Padilla C., Tamez-Guerra R. 5,5’-Biindole. Molbank. 2006; 2006(2):M474.

Chicago/Turabian Style

Quintanilla-Licea, Ramiro; Colunga-Valladares, Juan F.; Caballero-Quintero, Adolfo; Waksman, Noemí; Gomez-Flores, Ricardo; Rodríguez-Padilla, Cristina; Tamez-Guerra, Reyes. 2006. "5,5’-Biindole." Molbank 2006, no. 2: M474.

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