CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics

doi:10.3390/ijms9040668

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Int. J. Mol. Sci. 2008, 9(4), 668-678; doi:10.3390/ijms9040668

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CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics

Ke-Tai Guo, Gerhard Ziemer, Angela Paul and Hans P. Wendel *

Department of Thoracic, Cardiac and Vascular surgery, University Hospital Tuebingen, Tuebingen, Germany, Calwerstr.7/1, D72076 Tuebingen, Germany

* Author to whom correspondence should be addressed.

Received: 18 December 2007; in revised form: 3 April 2008 / Accepted: 24 April 2008 / Published: 24 April 2008

(This article belongs to the Special Issue Nucleic Acid Derivatives in Emerging Technologies)

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Abstract: Aptamers, single stranded DNA or RNA molecules, generated by a method called SELEX (systematic evolution of ligands by exponential enrichment) have been widely used in various biomedical applications. The newly developed Cell-SELEX (cell based-SELEX) targeting whole living cells has raised great expectations for cancer biology, -therapy and regenerative medicine. Combining nanobiotechnology with aptamers, this technology opens the way to more sophisticated applications in molecular diagnosis. This paper gives a review of recent developments in SELEX technologies and new applications of aptamers.

Keywords: cell-SELEX; aptamer; nanotechnology

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MDPI and ACS Style

Guo, K.-T.; Ziemer, G.; Paul, A.; Wendel, H.P. CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics. Int. J. Mol. Sci. 2008, 9, 668-678.

AMA Style

Guo K.-T., Ziemer G., Paul A., Wendel H.P. CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics. International Journal of Molecular Sciences. 2008; 9(4):668-678.

Chicago/Turabian Style

Guo, Ke-Tai; Ziemer, Gerhard; Paul, Angela; Wendel, Hans P. 2008. "CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics." Int. J. Mol. Sci. 9, no. 4: 668-678.

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