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CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics
Department of Thoracic, Cardiac and Vascular surgery, University Hospital Tuebingen, Tuebingen, Germany, Calwerstr.7/1, D72076 Tuebingen, Germany
* Author to whom correspondence should be addressed.
Received: 18 December 2007; in revised form: 3 April 2008 / Accepted: 24 April 2008 / Published: 24 April 2008
Abstract: Aptamers, single stranded DNA or RNA molecules, generated by a method called SELEX (systematic evolution of ligands by exponential enrichment) have been widely used in various biomedical applications. The newly developed Cell-SELEX (cell based-SELEX) targeting whole living cells has raised great expectations for cancer biology, -therapy and regenerative medicine. Combining nanobiotechnology with aptamers, this technology opens the way to more sophisticated applications in molecular diagnosis. This paper gives a review of recent developments in SELEX technologies and new applications of aptamers.
Keywords: cell-SELEX; aptamer; nanotechnology
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Guo, K.-T.; Ziemer, G.; Paul, A.; Wendel, H.P. CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics. Int. J. Mol. Sci. 2008, 9, 668-678.
Guo K-T, Ziemer G, Paul A, Wendel HP. CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics. International Journal of Molecular Sciences. 2008; 9(4):668-678.
Guo, Ke-Tai; Ziemer, Gerhard; Paul, Angela; Wendel, Hans P. 2008. "CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics." Int. J. Mol. Sci. 9, no. 4: 668-678.