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Int. J. Mol. Sci. 2008, 9(4), 571-577; doi:10.3390/ijms9040571

Extraction of Glycyrrhizic Acid and Glabridin from Licorice

Center for Advanced Bioseperation Technology, Department of Chemical Engineering, Inha University, Incheon 402-751, Korea
Author to whom correspondence should be addressed.
Received: 25 January 2008 / Revised: 18 February 2008 / Accepted: 12 March 2008 / Published: 16 April 2008
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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The extraction and separation conditions of glycyrrhizic acid and glabridin from licorice were investigated. By changing the different extraction solvents, procedures, times and temperature, the optimum extraction condition was established: the used of ethanol/water (30:70, v/v) as an extraction solvent, and 60 min dipping time under 50°C. The extracts of licorice were separated and determined by reversed-phase high performance liquid chromatography with a methanol/water (70:30, v/v, containing 1% acetic acid) as the mobile phase. Under the optimum extraction condition, 2.39 mg/g of glycyrrhizic acid and 0.92 mg/g of glabridin were extracted from Chinese licorice and the recoveries were 89.7% and 72.5% respectively.
Keywords: glycyrrhizic acid; glabridin; licorice; extraction; high-performance liquid chromatography glycyrrhizic acid; glabridin; licorice; extraction; high-performance liquid chromatography
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Tian, M.; Yan, H.; Row, K.H. Extraction of Glycyrrhizic Acid and Glabridin from Licorice. Int. J. Mol. Sci. 2008, 9, 571-577.

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