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Extraction of Glycyrrhizic Acid and Glabridin from Licorice
Center for Advanced Bioseperation Technology, Department of Chemical Engineering, Inha University, Incheon 402-751, Korea
* Author to whom correspondence should be addressed.
Received: 25 January 2008; in revised form: 18 February 2008 / Accepted: 12 March 2008 / Published: 16 April 2008
Abstract: The extraction and separation conditions of glycyrrhizic acid and glabridin from licorice were investigated. By changing the different extraction solvents, procedures, times and temperature, the optimum extraction condition was established: the used of ethanol/water (30:70, v/v) as an extraction solvent, and 60 min dipping time under 50°C. The extracts of licorice were separated and determined by reversed-phase high performance liquid chromatography with a methanol/water (70:30, v/v, containing 1% acetic acid) as the mobile phase. Under the optimum extraction condition, 2.39 mg/g of glycyrrhizic acid and 0.92 mg/g of glabridin were extracted from Chinese licorice and the recoveries were 89.7% and 72.5% respectively.
Keywords: glycyrrhizic acid; glabridin; licorice; extraction; high-performance liquid chromatography
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MDPI and ACS Style
Tian, M.; Yan, H.; Row, K.H. Extraction of Glycyrrhizic Acid and Glabridin from Licorice. Int. J. Mol. Sci. 2008, 9, 571-577.
Tian M, Yan H, Row KH. Extraction of Glycyrrhizic Acid and Glabridin from Licorice. International Journal of Molecular Sciences. 2008; 9(4):571-577.
Tian, Minglei; Yan, Hongyuan; Row, Kyung H. 2008. "Extraction of Glycyrrhizic Acid and Glabridin from Licorice." Int. J. Mol. Sci. 9, no. 4: 571-577.