Growth and Mycotoxin Production by Chaetomium globosum Is Favored in a Neutral pH

doi:10.3390/ijms9122357

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Int. J. Mol. Sci. 2008, 9(12), 2357-2365; doi:10.3390/ijms9122357

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Growth and Mycotoxin Production by Chaetomium globosum Is Favored in a Neutral pH

Matthew R. Fogle ¹, David R. Douglas ¹, Cynthia A. Jumper ² and David C. Straus ¹^,*

¹ Department of Microbiology and Immunology, Texas Tech University Health Sciences Center 3601 4th Street Mail stop 6591 Lubbock, TX 79430, USA ² Department of Internal Medicine, Texas Tech University Health Sciences Center 3601 4th Street Mail stop 6591 Lubbock, TX 79430, USA

* Author to whom correspondence should be addressed.

Received: 17 September 2008; in revised form: 31 October 2008 / Accepted: 25 November 2008 / Published: 26 November 2008

(This article belongs to the Special Issue Mycotoxins: Mechanisms of Toxicological Activity - Treatment and Prevention)

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Abstract: Chaetomium globosum is frequently isolated in water-damaged buildings and produces two mycotoxins called chaetoglobosins A and C when cultured on building material. In this study, the influence of ambient pH on the growth of C. globosum was examined on an artificial medium. This fungus was capable of growth on potato dextrose agar ranging in pH from 4.3 to 9.4 with optimal growth and chaetoglobosin C production occurring at a neutral pH. In addition, our results show that sporulation is favored in an acidic environment.

Keywords: Ambient pH; chaetoglobosin; Chaetomium globosum; indoor air quality; mycotoxin

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MDPI and ACS Style

Fogle, M.R.; Douglas, D.R.; Jumper, C.A.; Straus, D.C. Growth and Mycotoxin Production by Chaetomium globosum Is Favored in a Neutral pH. Int. J. Mol. Sci. 2008, 9, 2357-2365.

AMA Style

Fogle M.R., Douglas D.R., Jumper C.A., Straus D.C. Growth and Mycotoxin Production by Chaetomium globosum Is Favored in a Neutral pH. International Journal of Molecular Sciences. 2008; 9(12):2357-2365.

Chicago/Turabian Style

Fogle, Matthew R.; Douglas, David R.; Jumper, Cynthia A.; Straus, David C. 2008. "Growth and Mycotoxin Production by Chaetomium globosum Is Favored in a Neutral pH." Int. J. Mol. Sci. 9, no. 12: 2357-2365.

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