Int. J. Mol. Sci. 2008, 9(11), 2278-2289; https://doi.org/10.3390/ijms9112278
A Novel Co-polymer Based on Hydroxypropyl α-Cyclodextrin Conjugated to Low Molecular Weight Polyethylenimine as an in Vitro Gene Delivery Vector
1
School of Life Science, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou, P. R. China
2
Institute of Immunology, Zhejiang University, Yuhangtang Road 388, Hangzhou, P. R. China
3
Institute of Chemical Biology and Pharmaceutical Chemistry, Zhejiang University, Tianmushan Road 148, Hangzhou, P. R. China
*
Authors to whom correspondence should be addressed.
Received: 31 May 2008 / Revised: 4 November 2008 / Accepted: 7 November 2008 / Published: 21 November 2008
(This article belongs to the Special Issue Functional Materials- From Functional Hybrid Materials to Functional Polymers)
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Abstract
A novel co-polymer based on 2-hydroxypropyl-α-cyclodextrin cross-linked by low molecular weight polyethylenimine was synthesized as a gene delivery vector. The copolymer could bind and condense DNA tightly. It showed lower cytotoxicity than PEI 25kDa in SK-BR-3 cells. Transfection efficiency was increased over 5.5-fold higher than PEI 25 kDa in SK-BR-3 cells in complete serum medium. It is a potential candidate vector for gene therapy. View Full-TextKeywords:
Polyethylenimine; 2-hydroxypropyl-α-cyclodextrin; non-viral gene delivery vector; co-polymer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Huang, H.; Yu, H.; Li, D.; Liu, Y.; Shen, F.; Zhou, J.; Wang, Q.; Tang, G. A Novel Co-polymer Based on Hydroxypropyl α-Cyclodextrin Conjugated to Low Molecular Weight Polyethylenimine as an in Vitro Gene Delivery Vector. Int. J. Mol. Sci. 2008, 9, 2278-2289.
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