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Int. J. Mol. Sci. 2008, 9(11), 2278-2289; doi:10.3390/ijms9112278
Article

A Novel Co-polymer Based on Hydroxypropyl α-Cyclodextrin Conjugated to Low Molecular Weight Polyethylenimine as an in Vitro Gene Delivery Vector

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Received: 31 May 2008; in revised form: 4 November 2008 / Accepted: 7 November 2008 / Published: 21 November 2008
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Abstract: A novel co-polymer based on 2-hydroxypropyl-α-cyclodextrin cross-linked by low molecular weight polyethylenimine was synthesized as a gene delivery vector. The copolymer could bind and condense DNA tightly. It showed lower cytotoxicity than PEI 25kDa in SK-BR-3 cells. Transfection efficiency was increased over 5.5-fold higher than PEI 25 kDa in SK-BR-3 cells in complete serum medium. It is a potential candidate vector for gene therapy.
Keywords: Polyethylenimine; 2-hydroxypropyl-α-cyclodextrin; non-viral gene delivery vector; co-polymer Polyethylenimine; 2-hydroxypropyl-α-cyclodextrin; non-viral gene delivery vector; co-polymer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Huang, H.; Yu, H.; Li, D.; Liu, Y.; Shen, F.; Zhou, J.; Wang, Q.; Tang, G. A Novel Co-polymer Based on Hydroxypropyl α-Cyclodextrin Conjugated to Low Molecular Weight Polyethylenimine as an in Vitro Gene Delivery Vector. Int. J. Mol. Sci. 2008, 9, 2278-2289.

AMA Style

Huang H, Yu H, Li D, Liu Y, Shen F, Zhou J, Wang Q, Tang G. A Novel Co-polymer Based on Hydroxypropyl α-Cyclodextrin Conjugated to Low Molecular Weight Polyethylenimine as an in Vitro Gene Delivery Vector. International Journal of Molecular Sciences. 2008; 9(11):2278-2289.

Chicago/Turabian Style

Huang, Hongliang; Yu, Hai; Li, Da; Liu, Yang; Shen, Fenping; Zhou, Jun; Wang, Qingqing; Tang, Guping. 2008. "A Novel Co-polymer Based on Hydroxypropyl α-Cyclodextrin Conjugated to Low Molecular Weight Polyethylenimine as an in Vitro Gene Delivery Vector." Int. J. Mol. Sci. 9, no. 11: 2278-2289.



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