Int. J. Mol. Sci. 2008, 9(11), 2253-2264; doi:10.3390/ijms9112253
Article

Pravastatin Prevents Aortic Atherosclerosis via Modulation of Signal Transduction and Activation of Transcription 3 (STAT3) to Attenuate Interleukin-6 (IL-6) Action in ApoE Knockout Mice

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Received: 27 September 2008; in revised form: 4 November 2008 / Accepted: 7 November 2008 / Published: 14 November 2008
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The purpose of this study was to determine whether pravastatin’s prevention of aortic atherosclerosis via attenuation of IL-6 action depends on modulation of STAT3 activity. Male apoE knockout (apoE-/-) mice fed on a diet containing 1.25% cholesterol (wt/wt) were divided into pravastatin group provided with pravastatin (80 mg kg-1 per day) and atherosclerosis group. After eight weeks, pravastatin significantly prevented atherosclerotic lesion and reduced levels of IL-6 in serum and lesion, and significantly decreased expressions of phosphorylated STAT3 (pSTAT3) and increased suppressor of cytokine signaling 3 (SOCS3) expressions in lesions. Our results suggested that pravastatin’s aortic atherosclerosis preventing action via attenuation of IL-6 action may partially depend on modulation of STAT3 activity.
Keywords: Pravastatin; atherosclerosis; IL-6; STAT3; SOCS3
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MDPI and ACS Style

Zhou, X.; Li, D.; Yan, W.; Li, W. Pravastatin Prevents Aortic Atherosclerosis via Modulation of Signal Transduction and Activation of Transcription 3 (STAT3) to Attenuate Interleukin-6 (IL-6) Action in ApoE Knockout Mice. Int. J. Mol. Sci. 2008, 9, 2253-2264.

AMA Style

Zhou X, Li D, Yan W, Li W. Pravastatin Prevents Aortic Atherosclerosis via Modulation of Signal Transduction and Activation of Transcription 3 (STAT3) to Attenuate Interleukin-6 (IL-6) Action in ApoE Knockout Mice. International Journal of Molecular Sciences. 2008; 9(11):2253-2264.

Chicago/Turabian Style

Zhou, Xiaoxu; Li, Dan; Yan, Wei; Li, Weimin. 2008. "Pravastatin Prevents Aortic Atherosclerosis via Modulation of Signal Transduction and Activation of Transcription 3 (STAT3) to Attenuate Interleukin-6 (IL-6) Action in ApoE Knockout Mice." Int. J. Mol. Sci. 9, no. 11: 2253-2264.


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