Int. J. Mol. Sci. 2008, 9(11), 2243-2252; doi:10.3390/ijms9112243
Article

Effect of Several New and Currently Available Oxime Cholinesterase Reactivators on Tabun-intoxicated Rats

1,* email, 1email, 3, 1, 2 and 1,2email
Received: 16 October 2008; in revised form: 4 November 2008 / Accepted: 7 November 2008 / Published: 14 November 2008
(This article belongs to the Section Molecular Toxicology)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The therapeutical efficacies of eleven oxime-based acetylcholinesterase reactivators were compared in an in vivo (rat model) study of treatment of intoxication caused by tabun. In this group there were some currently available oximes (obidoxime, trimedoxime and HI-6) and the rest were newly synthesized compounds. The best reactivation efficacy for acetylcholinesterase in blood (expressed as percent of reactivation) among the currently available oximes was observed after administration of trimedoxime (16%) and of the newly synthesized K127 (22432) (25%). The reactivation of butyrylcholinesterase in plasma was also studied; the best reactivators were trimedoxime, K117 (22435), and K127 (22432), with overall reactivation efficacies of approximately 30%. Partial protection of brain ChE against tabun inhibition was observed after administration of trimedoxime (acetylcholinesterase 20%; butyrylcholinesterase 30%) and obidoxime (acetylcholinesterase 12%; butyrylcholinesterase 16%).
Keywords: Acetylcholinesterase; butyrylcholinesterase; reactivators; oximes; pretreatment
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MDPI and ACS Style

Karasova, J.Z.; Kassa, J.; Jung, Y.-S.; Musilek, K.; Pohanka, M.; Kuca, K. Effect of Several New and Currently Available Oxime Cholinesterase Reactivators on Tabun-intoxicated Rats. Int. J. Mol. Sci. 2008, 9, 2243-2252.

AMA Style

Karasova JZ, Kassa J, Jung Y-S, Musilek K, Pohanka M, Kuca K. Effect of Several New and Currently Available Oxime Cholinesterase Reactivators on Tabun-intoxicated Rats. International Journal of Molecular Sciences. 2008; 9(11):2243-2252.

Chicago/Turabian Style

Karasova, Jana Z.; Kassa, Jiri; Jung, Young-Sik; Musilek, Kamil; Pohanka, Miroslav; Kuca, Kamil. 2008. "Effect of Several New and Currently Available Oxime Cholinesterase Reactivators on Tabun-intoxicated Rats." Int. J. Mol. Sci. 9, no. 11: 2243-2252.

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