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Antibody-mediated Prevention of Fusarium Mycotoxins in the Field
Molecular Biotechnology Laboratory of Triticeae Crops, Huazhong Agricultural University, Wuhan 430070, P.R. China
College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, P.R. China
Laboratory of Structural Biochemistry, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia
* Author to whom correspondence should be addressed.
Received: 21 August 2008; in revised form: 26 September 2008 / Accepted: 6 October 2008 / Published: 9 October 2008
Abstract: Fusarium mycotoxins directly accumulated in grains during the infection of wheat and other cereal crops by Fusarium head blight (FHB) pathogens are detrimental to humans and domesticated animals. Prevention of the mycotoxins via the development of FHB-resistant varieties has been a challenge due to the scarcity of natural resistance against FHB pathogens. Various antibodies specific to Fusarium fungi and mycotoxins are widely used in immunoassays and antibody-mediated resistance in planta against Fusarium pathogens has been demonstrated. Antibodies fused to antifungal proteins have been shown to confer a very significantly enhanced Fusarium resistance in transgenic plants. Thus, antibody fusions hold great promise as an effective tool for the prevention of mycotoxin contaminations in cereal grains. This review highlights the utilization of protective antibodies derived from phage display to increase endogenous resistance of wheat to FHB pathogens and consequently to reduce mycotoxins in field. The role played by Fusarium-specific antibody in the resistance is also discussed.
Keywords: Antibody fusion; Fusarium mycotoxins; single-chain variable fragment
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MDPI and ACS Style
Hu, Z.-Q.; Li, H.-P.; Zhang, J.-B.; Glinka, E.; Liao, Y.-C. Antibody-mediated Prevention of Fusarium Mycotoxins in the Field. Int. J. Mol. Sci. 2008, 9, 1915-1926.
Hu Z-Q, Li H-P, Zhang J-B, Glinka E, Liao Y-C. Antibody-mediated Prevention of Fusarium Mycotoxins in the Field. International Journal of Molecular Sciences. 2008; 9(10):1915-1926.
Hu, Zu-Quan; Li, He-Ping; Zhang, Jing-Bo; Glinka, Elena; Liao, Yu-Cai. 2008. "Antibody-mediated Prevention of Fusarium Mycotoxins in the Field." Int. J. Mol. Sci. 9, no. 10: 1915-1926.