Int. J. Mol. Sci. 2008, 9(1), 56-64; doi:10.3390/ijms9010056
Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
Chair and Department of Microbiology and Immunology, Jordana 19, 41 808 Zabrze
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Received: 16 August 2007 / Revised: 3 January 2008 / Accepted: 17 January 2008 / Published: 21 January 2008
(This article belongs to the Special Issue Natural Compounds for Cancer Treatment and Prevention)
Abstract
TRAIL is a promising candidate for cancer therapeutics that preferentially induces apoptosis in cancer cells. The combined treatment flavonoids with TRAIL might be promising as a chemoprevention and/or new therapy against malignant tumors. We examined the cytotoxic effect of dietary flavonoids in combination with TRAIL on HeLa cells. It was found that treatment with noncytotoxic concentration of some flavonoids significantly sensititizes to TRAIL induced death in HeLa cells. Our study demonstrated that flavone, apigenin and genistein markedly augmented TRAIL mediated cytotoxicity against HeLa, whereas kaempferol and quercetin produced no effect.Keywords:
Dietary flavonoids; TRAIL; HeLa; chemoprevention; antitumoral activity.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Szliszka, E.; Czuba, Z.P.; Jernas, K.; Król, W. Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL). Int. J. Mol. Sci. 2008, 9, 56-64.
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