Int. J. Mol. Sci. 2008, 9(1), 56-64; doi:10.3390/ijms9010056
Article

Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

Ewelina Szliszka, Zenon P. Czubaemail, Katarzyna Jernas and Wojciech Król* email
Chair and Department of Microbiology and Immunology, Jordana 19, 41 808 Zabrze
* Author to whom correspondence should be addressed.
Received: 16 August 2007; in revised form: 3 January 2008 / Accepted: 17 January 2008 / Published: 21 January 2008
(This article belongs to the Special Issue Natural Compounds for Cancer Treatment and Prevention)
PDF Full-text Download PDF Full-Text [121 KB, uploaded 2 October 2008 12:05 CEST]
Abstract: TRAIL is a promising candidate for cancer therapeutics that preferentially induces apoptosis in cancer cells. The combined treatment flavonoids with TRAIL might be promising as a chemoprevention and/or new therapy against malignant tumors. We examined the cytotoxic effect of dietary flavonoids in combination with TRAIL on HeLa cells. It was found that treatment with noncytotoxic concentration of some flavonoids significantly sensititizes to TRAIL induced death in HeLa cells. Our study demonstrated that flavone, apigenin and genistein markedly augmented TRAIL mediated cytotoxicity against HeLa, whereas kaempferol and quercetin produced no effect.
Keywords: Dietary flavonoids; TRAIL; HeLa; chemoprevention; antitumoral activity.

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Szliszka, E.; Czuba, Z.P.; Jernas, K.; Król, W. Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL). Int. J. Mol. Sci. 2008, 9, 56-64.

AMA Style

Szliszka E, Czuba ZP, Jernas K, Król W. Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL). International Journal of Molecular Sciences. 2008; 9(1):56-64.

Chicago/Turabian Style

Szliszka, Ewelina; Czuba, Zenon P.; Jernas, Katarzyna; Król, Wojciech. 2008. "Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)." Int. J. Mol. Sci. 9, no. 1: 56-64.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert