Dinuclear Zinc (II) Complexes of Macrocyclic Polyamine Ligands Containing an Imidazolium Bridge: Synthesis, Characterization, and Their Interaction with Plasmid DNA

doi:10.3390/i8070606

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Int. J. Mol. Sci. 2007, 8(7), 606-617; doi:10.3390/i8070606

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Dinuclear Zinc (II) Complexes of Macrocyclic Polyamine Ligands Containing an Imidazolium Bridge: Synthesis, Characterization, and Their Interaction with Plasmid DNA

Jun Huang ¹, Qing-Dong Huang ¹, Ji Zhang ¹, Li-Hong Zhou ¹, Qiang-Lin Li ¹, Kun Li ¹, Ning Jiang ², Hong-Hui Lin ², Jiang Wu ¹ and Xiao-Qi Yu ¹^,*

¹ Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, Chengdu, 610064, P. R. China ² Key Laboratory of Bio-resources and Eco-environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu, Sichuan, 610064, P. R. China ³ State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P. R .China

* Author to whom correspondence should be addressed.

Received: 6 March 2007; in revised form: 6 June 2007 / Accepted: 14 June 2007 / Published: 4 July 2007

(This article belongs to the Special Issue Nucleic Acid Derivatives in Emerging Technologies)

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Abstract: Two novel macrocyclic polyamine ligands and their dinuclear zinc (II)complexes were synthesized and characterized. Their interaction with plasmid DNA wasstudied by gel electrophoresis and fluorescence quenching experiment. The result showedthat these complexes could bind DNA efficiently under physiological conditions.

Keywords: 1,4,7,10-tetraazacyclododecane (cyclen); zinc (II) complexes; imidazolium; synthesis; DNA protection.

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MDPI and ACS Style

Huang, J.; Huang, Q.-D.; Zhang, J.; Zhou, L.-H.; Li, Q.-L.; Li, K.; Jiang, N.; Lin, H.-H.; Wu, J.; Yu, X.-Q. Dinuclear Zinc (II) Complexes of Macrocyclic Polyamine Ligands Containing an Imidazolium Bridge: Synthesis, Characterization, and Their Interaction with Plasmid DNA. Int. J. Mol. Sci. 2007, 8, 606-617.

AMA Style

Huang J., Huang Q.-D., Zhang J., Zhou L.-H., Li Q.-L., Li K., Jiang N., Lin H.-H., Wu J., Yu X.-Q. Dinuclear Zinc (II) Complexes of Macrocyclic Polyamine Ligands Containing an Imidazolium Bridge: Synthesis, Characterization, and Their Interaction with Plasmid DNA. International Journal of Molecular Sciences. 2007; 8(7):606-617.

Chicago/Turabian Style

Huang, Jun; Huang, Qing-Dong; Zhang, Ji; Zhou, Li-Hong; Li, Qiang-Lin; Li, Kun; Jiang, Ning; Lin, Hong-Hui; Wu, Jiang; Yu, Xiao-Qi. 2007. "Dinuclear Zinc (II) Complexes of Macrocyclic Polyamine Ligands Containing an Imidazolium Bridge: Synthesis, Characterization, and Their Interaction with Plasmid DNA." Int. J. Mol. Sci. 8, no. 7: 606-617.

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