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Microwave-Assisted Synthesis of Phenothiazine and Qinoline Derivatives
“Babeș-Bolyai” University, Faculty of Chemistry and Chemical Engineering, Organic Chemistry Department, Cluj-Napoca, Romania
Institute of Organic Chemistry, National NMR Laboratory, Bucharest, Romania
Universitée de la Mediteranée, Faculté de Pharmacie, Marseille, France
* Author to whom correspondence should be addressed.
Received: 27 October 2006 / Accepted: 12 February 2007 / Published: 13 February 2007
Abstract: Application of a dynamic microwave power system in the chemical synthesis ofsome phenothiazine and quinoline derivatives is described. Heterocyclic ring formation,aromatic nucleophilic substitution and heterocyclic aldehydes/ketones condensationreactions were performed on solid support, or under solvent free reaction conditions. Themicrowave-assisted Duff formylation of phenothiazine was achieved. Comparison ofmicrowave-assisted synthesis with the conventional synthetic methods demonstratesadvantages related to shorter reaction times and in some cases better reaction yields.
Keywords: MAOS; Quinoline; Pyrido[3,2-g]quinoline; Phenothiazine; formylation
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Găină, L.; Cristea, C.; Moldovan, C.; Porumb, D.; Surducan, E.; Deleanu, C.; Mahamoud, A.; Barbe, J.; Silberg, I.A. Microwave-Assisted Synthesis of Phenothiazine and Qinoline Derivatives. Int. J. Mol. Sci. 2007, 8, 70-80.
Găină L, Cristea C, Moldovan C, Porumb D, Surducan E, Deleanu C, Mahamoud A, Barbe J, Silberg IA. Microwave-Assisted Synthesis of Phenothiazine and Qinoline Derivatives. International Journal of Molecular Sciences. 2007; 8(2):70-80.
Găină, Luiza; Cristea, Castelia; Moldovan, Claudia; Porumb, Dan; Surducan, Emanoil; Deleanu, Calin; Mahamoud, Abdalah; Barbe, Jacques; Silberg, Ioan A. 2007. "Microwave-Assisted Synthesis of Phenothiazine and Qinoline Derivatives." Int. J. Mol. Sci. 8, no. 2: 70-80.