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Int. J. Mol. Sci. 2007, 8(2), 70-80; doi:10.3390/i8020070
Article

Microwave-Assisted Synthesis of Phenothiazine and Qinoline Derivatives

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Received: 27 October 2006 / Accepted: 12 February 2007 / Published: 13 February 2007
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Abstract

Application of a dynamic microwave power system in the chemical synthesis ofsome phenothiazine and quinoline derivatives is described. Heterocyclic ring formation,aromatic nucleophilic substitution and heterocyclic aldehydes/ketones condensationreactions were performed on solid support, or under solvent free reaction conditions. Themicrowave-assisted Duff formylation of phenothiazine was achieved. Comparison ofmicrowave-assisted synthesis with the conventional synthetic methods demonstratesadvantages related to shorter reaction times and in some cases better reaction yields.
Keywords: MAOS; Quinoline; Pyrido[3,2-g]quinoline; Phenothiazine; formylation MAOS; Quinoline; Pyrido[3,2-g]quinoline; Phenothiazine; formylation
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Găină, L.; Cristea, C.; Moldovan, C.; Porumb, D.; Surducan, E.; Deleanu, C.; Mahamoud, A.; Barbe, J.; Silberg, I.A. Microwave-Assisted Synthesis of Phenothiazine and Qinoline Derivatives. Int. J. Mol. Sci. 2007, 8, 70-80.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert