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Int. J. Mol. Sci. 2007, 8(12), 1225-1233; doi:10.3390/i8121233

The Interaction of Sheep Genomic DNA with a Cobalt(II) Complex Containing p-Nitrobenzoate and N,N`-Diethylnicotinamide Ligands

1
Department of Chemistry, Faculty of Arts and Sciences, Kafkas University, 36300 Kars, Turkey
2
Department of Biochemistry, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey
*
Author to whom correspondence should be addressed.
Received: 15 May 2007 / Revised: 16 November 2007 / Accepted: 23 November 2007 / Published: 13 December 2007
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The synthesized cobalt(II) complex, CoPNBDENA and the binding of thiscomplex with sheep genomic DNA were investigated by UV–Visible absorption andviscosity techniques. Also the interaction of sheep genomic DNA with the complex wasstudied using the agarose gel electrophoresis method. The results indicated that thecomplex interacted with DNA. The nature of the binding seemed to be mainly anelectrostatic interaction between DNA and the cobalt(II) complex. Other binding modessuch as hydrogen bonds may also exist in this system. In this study, after the interaction ofDNA– CoPNBDENA, it was observed that the migration of the DNA band became slow asthe amount of cobalt(II) complex was increased. This clearly demonstrates that theCoPNBDENA complex neutralizes the negative charges of DNA.
Keywords: DNA-metal interaction; Cobalt(II) complex; Sheep genomic DNA; pnitrobenzoate; N; N`-Diethylnicotinamid DNA-metal interaction; Cobalt(II) complex; Sheep genomic DNA; pnitrobenzoate; N; N`-Diethylnicotinamid
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Arslantas, A.; Devrim, A.K.; Necefoglu, H. The Interaction of Sheep Genomic DNA with a Cobalt(II) Complex Containing p-Nitrobenzoate and N,N`-Diethylnicotinamide Ligands. Int. J. Mol. Sci. 2007, 8, 1225-1233.

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