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Electrochemical Studies of Camptothecin and Its Interaction with Human Serum Albumin
Department of Biochemistry and National Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China
School of Life Science and Shanghai Key Laboratory of Bio-Energy Crops, Shanghai University, Shanghai 200444, P. R. China
* Author to whom correspondence should be addressed.
Received: 4 January 2007 / Accepted: 25 January 2007 / Published: 30 January 2007
Abstract: Camptothecin, an anticancer component from Camptotheca acuminate, mayinteract with human serum albumin (HSA) at the subdomain IIA (site I), and then convert toits inactive form(carboxylate form). In this paper, the detailed electrochemical behaviors ofcamptothecin at a pyrolytic graphite electrode is presented. The interaction betweencamptothecin and HSA is also studied by electrochemical technique. By comparing withbovine serum albumin (BSA), which is highly homologous to HSA, we prove thatcamptothecin can specifically bind to HSA. Meanwhile, the inhibitory influence of sodiumsalicylate to this binding is also discussed.
Keywords: Camptothecin; human serum albumin; cyclic voltammetry
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MDPI and ACS Style
Zhao, J.; Zheng, X.; Xing, W.; Huang, J.; Li, G. Electrochemical Studies of Camptothecin and Its Interaction with Human Serum Albumin. Int. J. Mol. Sci. 2007, 8, 42-50.
Zhao J, Zheng X, Xing W, Huang J, Li G. Electrochemical Studies of Camptothecin and Its Interaction with Human Serum Albumin. International Journal of Molecular Sciences. 2007; 8(1):42-50.
Zhao, Jing; Zheng, Xiaofeng; Xing, Wei; Huang, Junyi; Li, Genxi. 2007. "Electrochemical Studies of Camptothecin and Its Interaction with Human Serum Albumin." Int. J. Mol. Sci. 8, no. 1: 42-50.