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Int. J. Mol. Sci. 2007, 8(1), 42-50; doi:10.3390/i8010042
Article

Electrochemical Studies of Camptothecin and Its Interaction with Human Serum Albumin

1, 1, 1, 2 and 1,*
Received: 4 January 2007; Accepted: 25 January 2007 / Published: 30 January 2007
(This article belongs to the Special Issue Interaction of Biological Molecules)
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Abstract: Camptothecin, an anticancer component from Camptotheca acuminate, mayinteract with human serum albumin (HSA) at the subdomain IIA (site I), and then convert toits inactive form(carboxylate form). In this paper, the detailed electrochemical behaviors ofcamptothecin at a pyrolytic graphite electrode is presented. The interaction betweencamptothecin and HSA is also studied by electrochemical technique. By comparing withbovine serum albumin (BSA), which is highly homologous to HSA, we prove thatcamptothecin can specifically bind to HSA. Meanwhile, the inhibitory influence of sodiumsalicylate to this binding is also discussed.
Keywords: Camptothecin; human serum albumin; cyclic voltammetry Camptothecin; human serum albumin; cyclic voltammetry
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhao, J.; Zheng, X.; Xing, W.; Huang, J.; Li, G. Electrochemical Studies of Camptothecin and Its Interaction with Human Serum Albumin. Int. J. Mol. Sci. 2007, 8, 42-50.

AMA Style

Zhao J, Zheng X, Xing W, Huang J, Li G. Electrochemical Studies of Camptothecin and Its Interaction with Human Serum Albumin. International Journal of Molecular Sciences. 2007; 8(1):42-50.

Chicago/Turabian Style

Zhao, Jing; Zheng, Xiaofeng; Xing, Wei; Huang, Junyi; Li, Genxi. 2007. "Electrochemical Studies of Camptothecin and Its Interaction with Human Serum Albumin." Int. J. Mol. Sci. 8, no. 1: 42-50.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert