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Int. J. Mol. Sci. 2006, 7(4), 119-129; doi:10.3390/i7040119
Article

QSAR of Some N1-Aryl/Heteroarylaminomethyl/ethyl-1,2,4-Triazoles Part II: Antimicrobial Activity Against BacillusSubtilis

1,* , 1 and 2
1 Faculty of Technology and Metallurgy, The “Sv. Kiril & Metodij” University, Ruger Boskovic 16, 1000 Skopje, Macedonia 2 Faculty of Agriculture, Department of Microbiology, The “Sv. Kiril & Metodij” University, bul. Aleksandar Makedonski, bb, 1000 Skopje, Macedonia
* Author to whom correspondence should be addressed.
Received: 27 December 2005 / Revised: 15 August 2006 / Accepted: 20 April 2006 / Published: 26 April 2006
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Abstract

QSAR analysis of a series of previously synthesized N1-aryl-amino/methyl/ethyl-1,2,4-triazole and N1-heteroarylamino/methyl/ethyl-1,2,4-triazolederivatives tested for growth inhibitory activity against Bacillus subtilis, was performedusing the computer-assisted multiple regression procedure. Using the Hansch and FreeWilson approaches the activity contribution for either the aminomethyl/aminoethyl unitor the aromatic/heteroaromatic ring was determined from the correlation equation.
Keywords: QSAR/QSPR; N1-heteroarylamino/methyl/ethyl-1; 2; 4-triazole; physico- chemical parameters QSAR/QSPR; N1-heteroarylamino/methyl/ethyl-1; 2; 4-triazole; physico- chemical parameters
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Dimova, V.; Ragenovic, K.C.; Kakurinov, V. QSAR of Some N1-Aryl/Heteroarylaminomethyl/ethyl-1,2,4-Triazoles Part II: Antimicrobial Activity Against BacillusSubtilis. Int. J. Mol. Sci. 2006, 7, 119-129.

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