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Int. J. Mol. Sci. 2006, 7(4), 119-129; doi:10.3390/i7040119
Article

QSAR of Some N1-Aryl/Heteroarylaminomethyl/ethyl-1,2,4-Triazoles Part II: Antimicrobial Activity Against BacillusSubtilis

1,* , 1 and 2
1 Faculty of Technology and Metallurgy, The “Sv. Kiril & Metodij” University, Ruger Boskovic 16, 1000 Skopje, Macedonia 2 Faculty of Agriculture, Department of Microbiology, The “Sv. Kiril & Metodij” University, bul. Aleksandar Makedonski, bb, 1000 Skopje, Macedonia
* Author to whom correspondence should be addressed.
Received: 27 December 2005 / Revised: 15 August 2006 / Accepted: 20 April 2006 / Published: 26 April 2006
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Abstract

QSAR analysis of a series of previously synthesized N1-aryl-amino/methyl/ethyl-1,2,4-triazole and N1-heteroarylamino/methyl/ethyl-1,2,4-triazolederivatives tested for growth inhibitory activity against Bacillus subtilis, was performedusing the computer-assisted multiple regression procedure. Using the Hansch and FreeWilson approaches the activity contribution for either the aminomethyl/aminoethyl unitor the aromatic/heteroaromatic ring was determined from the correlation equation.
Keywords: QSAR/QSPR; N1-heteroarylamino/methyl/ethyl-1; 2; 4-triazole; physico- chemical parameters QSAR/QSPR; N1-heteroarylamino/methyl/ethyl-1; 2; 4-triazole; physico- chemical parameters
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dimova, V.; Ragenovic, K.C.; Kakurinov, V. QSAR of Some N1-Aryl/Heteroarylaminomethyl/ethyl-1,2,4-Triazoles Part II: Antimicrobial Activity Against BacillusSubtilis. Int. J. Mol. Sci. 2006, 7, 119-129.

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