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Int. J. Mol. Sci. 2018, 19(9), 2680; https://doi.org/10.3390/ijms19092680

Structural Basis for the Lipopolysaccharide Export Activity of the Bacterial Lipopolysaccharide Transport System

Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, Canada
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Received: 20 August 2018 / Revised: 4 September 2018 / Accepted: 5 September 2018 / Published: 10 September 2018
(This article belongs to the Special Issue Lipopolysaccharides (LPSs) 2018)
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Abstract

Gram-negative bacteria have a dense outer membrane (OM) coating of lipopolysaccharides, which is essential to their survival. This coating is assembled by the LPS (lipopolysaccharide) transport (Lpt) system, a coordinated seven-subunit protein complex that spans the cellular envelope. LPS transport is driven by an ATPase-dependent mechanism dubbed the “PEZ” model, whereby a continuous stream of LPS molecules is pushed from subunit to subunit. This review explores recent structural and functional findings that have elucidated the subunit-scale mechanisms of LPS transport, including the novel ABC-like mechanism of the LptB2FG subcomplex and the lateral insertion of LPS into the OM by LptD/E. New questions are also raised about the functional significance of LptA oligomerization and LptC. The tightly regulated interactions between these connected subcomplexes suggest a pathway that can react dynamically to membrane stress and may prove to be a valuable target for new antibiotic therapies for Gram-negative pathogens. View Full-Text
Keywords: lipopolysaccharides; membrane transport; Gram-negative bacteria lipopolysaccharides; membrane transport; Gram-negative bacteria
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Hicks, G.; Jia, Z. Structural Basis for the Lipopolysaccharide Export Activity of the Bacterial Lipopolysaccharide Transport System. Int. J. Mol. Sci. 2018, 19, 2680.

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