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Int. J. Mol. Sci. 2018, 19(8), 2362; https://doi.org/10.3390/ijms19082362

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

1
Department of Zoology, Yashwantrao Chavan Institute of Science, Satara, Maharashtra 415001, India
2
Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India
3
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam
4
Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam
5
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore
6
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore
7
Medical Science Cluster, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore
8
Curtin Medical School, Faculty of Health Sciences, Curtin University, Perth, WA 6009, Australia
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 28 July 2018 / Revised: 6 August 2018 / Accepted: 8 August 2018 / Published: 10 August 2018
(This article belongs to the Special Issue Alterations to Signalling Pathways in Cancer Cells 2018)
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Abstract

The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will increase in future and will create global havoc, designating it as an epidemic. Conventional chemotherapeutics and treatment with synthetic disciplines are often associated with adverse side effects and development of chemoresistance. Thus, discovering novel economic and patient friendly drugs that are safe and efficacious is warranted. Several natural compounds have proved their potential against this dreadful disease so far. Magnolol is a hydroxylated biphenyl isolated from the root and stem bark of Magnolia tree. Magnolol can efficiently prevent or inhibit the growth of various cancers originating from different organs such as brain, breast, cervical, colon, liver, lung, prostate, skin, etc. Considering these perspectives, the current review primarily focuses on the fascinating role of magnolol against various types of cancers, and the source and chemistry of magnolol and the molecular mechanism underlying the targets of magnolol are discussed. This review proposes magnolol as a suitable candidate that can be appropriately designed and established into a potent anti-cancer drug. View Full-Text
Keywords: magnolol; cancer; phytochemicals; molecular targets; chemoresistance magnolol; cancer; phytochemicals; molecular targets; chemoresistance
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Ranaware, A.M.; Banik, K.; Deshpande, V.; Padmavathi, G.; Roy, N.K.; Sethi, G.; Fan, L.; Kumar, A.P.; Kunnumakkara, A.B. Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer. Int. J. Mol. Sci. 2018, 19, 2362.

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