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Int. J. Mol. Sci. 2018, 19(8), 2343; https://doi.org/10.3390/ijms19082343

Mesenchymal Stem Cell Migration during Bone Formation and Bone Diseases Therapy

1,2,3,†
,
1,2,3,†
,
1,2,3
,
1,2,3
,
1,2,3
,
1,2,3
and
1,2,3,*
1
Lab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, China
2
Research Center for Special Medicine and Health Systems Engineering, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, China
3
NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, China
These authors contribute equally to this work.
*
Author to whom correspondence should be addressed.
Received: 5 June 2018 / Revised: 2 August 2018 / Accepted: 6 August 2018 / Published: 9 August 2018
(This article belongs to the Special Issue Tumor Bone Microenvironment, Bone Turnover and Stem Cell)
View Full-Text   |   Download PDF [1041 KB, uploaded 9 August 2018]   |  

Abstract

During bone modeling, remodeling, and bone fracture repair, mesenchymal stem cells (MSCs) differentiate into chondrocyte or osteoblast to comply bone formation and regeneration. As multipotent stem cells, MSCs were used to treat bone diseases during the past several decades. However, most of these implications just focused on promoting MSC differentiation. Furthermore, cell migration is also a key issue for bone formation and bone diseases treatment. Abnormal MSC migration could cause different kinds of bone diseases, including osteoporosis. Additionally, for bone disease treatment, the migration of endogenous or exogenous MSCs to bone injury sites is required. Recently, researchers have paid more and more attention to two critical points. One is how to apply MSC migration to bone disease therapy. The other is how to enhance MSC migration to improve the therapeutic efficacy of bone diseases. Some considerable outcomes showed that enhancing MSC migration might be a novel trick for reversing bone loss and other bone diseases, such as osteoporosis, fracture, and osteoarthritis (OA). Although plenty of challenges need to be conquered, application of endogenous and exogenous MSC migration and developing different strategies to improve therapeutic efficacy through enhancing MSC migration to target tissue might be the trend in the future for bone disease treatment. View Full-Text
Keywords: mesenchymal stem cells; migration; bone formation; bone diseases; therapy mesenchymal stem cells; migration; bone formation; bone diseases; therapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Su, P.; Tian, Y.; Yang, C.; Ma, X.; Wang, X.; Pei, J.; Qian, A. Mesenchymal Stem Cell Migration during Bone Formation and Bone Diseases Therapy. Int. J. Mol. Sci. 2018, 19, 2343.

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