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Int. J. Mol. Sci. 2018, 19(7), 2043; https://doi.org/10.3390/ijms19072043

Role of mTOR in Glucose and Lipid Metabolism

1
and
1,2,*
1
Center for Diabetes, Obesity and Metabolism, Department of Physiology, Shenzhen University Health Science Center, Shenzhen 518060, China
2
Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China
*
Author to whom correspondence should be addressed.
Received: 31 May 2018 / Revised: 10 July 2018 / Accepted: 11 July 2018 / Published: 13 July 2018
(This article belongs to the Special Issue mTOR in Human Diseases)
View Full-Text   |   Download PDF [491 KB, uploaded 13 July 2018]   |  

Abstract

The mammalian target of rapamycin, mTOR is the master regulator of a cell’s growth and metabolic state in response to nutrients, growth factors and many extracellular cues. Its dysregulation leads to a number of metabolic pathological conditions, including obesity and type 2 diabetes. Here, we review recent findings on the role of mTOR in major metabolic organs, such as adipose tissues, liver, muscle, pancreas and brain. And their potentials as the mTOR related pharmacological targets will be also discussed. View Full-Text
Keywords: mTOR; metabolic diseases; glucose and lipid metabolism mTOR; metabolic diseases; glucose and lipid metabolism
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Mao, Z.; Zhang, W. Role of mTOR in Glucose and Lipid Metabolism. Int. J. Mol. Sci. 2018, 19, 2043.

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