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Int. J. Mol. Sci. 2018, 19(7), 2040; https://doi.org/10.3390/ijms19072040

Implications of AMPK in the Formation of Epithelial Tight Junctions

1
Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), Cardiovascular Sciences, University of Liège (ULiège), Avenue de L'Hôpital 11, 4000 Liège, Belgium
2
Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06520, USA
3
Division of Nephrology, Centre Hospitalier Universitaire de Liège (CHU of Liège), University of Liège (CHU ULiège), 13-B4000 Liège, Belgium
*
Author to whom correspondence should be addressed.
Received: 12 June 2018 / Revised: 9 July 2018 / Accepted: 9 July 2018 / Published: 13 July 2018
(This article belongs to the Special Issue AMP-Activated Protein Kinase Signalling)
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Abstract

Tight junctions (TJ) play an essential role in the epithelial barrier. By definition, TJ are located at the demarcation between the apical and baso-lateral domains of the plasma membrane in epithelial cells. TJ fulfill two major roles: (i) TJ prevent the mixing of membrane components; and (ii) TJ regulate the selective paracellular permeability. Disruption of TJ is regarded as one of the earliest hallmarks of epithelial injury, leading to the loss of cell polarity and tissue disorganization. Many factors have been identified as modulators of TJ assembly/disassembly. More specifically, in addition to its role as an energy sensor, adenosine monophosphate-activated protein kinase (AMPK) participates in TJ regulation. AMPK is a ubiquitous serine/threonine kinase composed of a catalytic α-subunit complexed with regulatory β-and γ-subunits. AMPK activation promotes the early stages of epithelial TJ assembly. AMPK phosphorylates the adherens junction protein afadin and regulates its interaction with the TJ-associated protein zonula occludens (ZO)-1, thereby facilitating ZO-1 distribution to the plasma membrane. In the present review, we detail the signaling pathways up-and down-stream of AMPK activation at the time of Ca2+-induced TJ assembly. View Full-Text
Keywords: AMPK; tight junctions; epithelial cells; ZO-1; par complex; MDCK; nectin-afadin; adherent junctions AMPK; tight junctions; epithelial cells; ZO-1; par complex; MDCK; nectin-afadin; adherent junctions
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Rowart, P.; Wu, J.; Caplan, M.J.; Jouret, F. Implications of AMPK in the Formation of Epithelial Tight Junctions. Int. J. Mol. Sci. 2018, 19, 2040.

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