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Int. J. Mol. Sci. 2018, 19(6), 1745; https://doi.org/10.3390/ijms19061745

Peribiliary Glands as the Cellular Origin of Biliary Tract Cancer

Department of Gastroenterology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
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Received: 24 May 2018 / Revised: 8 June 2018 / Accepted: 10 June 2018 / Published: 12 June 2018
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Abstract

The identification of the cellular origin of cancer is important for our understanding of the mechanisms regulating carcinogenesis, thus the cellular origin of cholangiocarcinoma (CCA) is a current topic of interest. Although CCA has been considered to originate from biliary epithelial cells, recent studies have suggested that multiple cell types can develop into CCA. With regard to the hilar and extrahepatic bile ducts, peribiliary glands (PBGs), a potential stem cell niche of biliary epithelial cells, have attracted attention as the cellular origin of biliary tract cancer. Recent histopathological and experimental studies have suggested that some kinds of inflammation-induced CCA and intraductal papillary neoplasms of the bile duct are more likely to originate from PBGs. During inflammation-mediated cholangiocarcinogenesis, the biliary epithelial injury-induced regenerative response by PBGs is considered a key process. Thus, in this review, we discuss recent advances in our understanding of cholangiocarcinogenesis from the viewpoint of inflammation and the cellular origin of CCA, especially focusing on PBGs. View Full-Text
Keywords: peribiliary gland; cholangiocarcinoma; interleukin (IL)-33; intraductal papillary neoplasm of biliary duct; mouse model; stem cell peribiliary gland; cholangiocarcinoma; interleukin (IL)-33; intraductal papillary neoplasm of biliary duct; mouse model; stem cell
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Nakagawa, H.; Hayata, Y.; Yamada, T.; Kawamura, S.; Suzuki, N.; Koike, K. Peribiliary Glands as the Cellular Origin of Biliary Tract Cancer. Int. J. Mol. Sci. 2018, 19, 1745.

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