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Int. J. Mol. Sci. 2018, 19(6), 1726; https://doi.org/10.3390/ijms19061726

Phoenixin—A Pleiotropic Gut-Brain Peptide

1
Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany
2
Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, 72076 Tübingen, Germany
*
Author to whom correspondence should be addressed.
Received: 30 April 2018 / Revised: 28 May 2018 / Accepted: 8 June 2018 / Published: 11 June 2018
(This article belongs to the Special Issue The (Microbiota)–Gut–Brain Axis: Hype or Revolution?)
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Abstract

Phoenixin is a recently discovered brain peptide initially thought to be restricted to reproductive functions. The subsequent identification of phoenixin’s expression in peripheral tissues was accompanied by the description of several other actions of this hormone, such as effects on behavior, sensory perception, memory retention, the cardiovascular system as well as food intake, pointing towards a pleiotropic role of this peptide. The present review will discuss the present knowledge on phoenixin and the signaling involved as well as highlight gaps in knowledge to stimulate further research. View Full-Text
Keywords: central nervous system; food intake; gastrointestinal tract; gut-brain axis; gut hormone; neuropeptide; orexigenic; phoenixin-14; phoenixin-20 central nervous system; food intake; gastrointestinal tract; gut-brain axis; gut hormone; neuropeptide; orexigenic; phoenixin-14; phoenixin-20
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Schalla, M.A.; Stengel, A. Phoenixin—A Pleiotropic Gut-Brain Peptide. Int. J. Mol. Sci. 2018, 19, 1726.

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