Effects of Sparassis crispa in Medical Therapeutics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
AbstractIn this study, we investigated the therapeutic potential and medical applications of Sparassis crispa (S. crispa) by conducting a systematic review of the existing literature and performing a meta-analysis. The original efficacy treatment of the mushroom extract is considered primarily and searched in electronic databases. A total of 623 articles were assessed, 33 randomized controlled experiments were included after the manual screening, and some papers, review articles, or editorials that did not contain data were excluded. A comparative standard means difference (SMD) and a funnel plot between control and S. crispa groups were used as parameters to demonstrate the beneficial effects of S. crispa for diabetes and cancer treatment, as well as anti-inflammatory, anti-fungal and antioxidant activities. The meta-analysis was carried out using Review Manager 5.1 software. Although for therapeutic diabetes there was heterogeneity in the subgroup analysis (I2 = 91.9%), the overall results showed statistically significant SMDs in major symptoms that decreased serum insulin levels (SMD = 1.92, 95% CI (1.10, 2.75), I2 = 0%), wound rates (SMD = 3.55 (2.56, 4.54), I2 = 40%) and contributions to an increase in nutrient intake content (SMD = 0.32 (−0.15, 0.78), I2 = 0%). Simultaneously, the study confirmed the utility of S. crispa treatment in terms of not only anti-cancer activity (reduction of tumor activity and survival of cancer cells I2 = 42 and 34%, respectively) but also anti-inflammatory, anti-fungal and antioxidant activities (I2 = 50, 44, and 10%, respectively). Our findings suggest that S. crispa extracts are useful for prevention and treatment of human diseases and might be the best candidates for future medicines. View Full-Text
Share & Cite This Article
Thi Nhu Ngoc, L.; Oh, Y.-K.; Lee, Y.-J.; Lee, Y.-C. Effects of Sparassis crispa in Medical Therapeutics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Int. J. Mol. Sci. 2018, 19, 1487.
Thi Nhu Ngoc L, Oh Y-K, Lee Y-J, Lee Y-C. Effects of Sparassis crispa in Medical Therapeutics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Molecular Sciences. 2018; 19(5):1487.Chicago/Turabian Style
Thi Nhu Ngoc, Le; Oh, You-Kwan; Lee, Young-Jong; Lee, Young-Chul. 2018. "Effects of Sparassis crispa in Medical Therapeutics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Int. J. Mol. Sci. 19, no. 5: 1487.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.