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Int. J. Mol. Sci. 2018, 19(5), 1474; https://doi.org/10.3390/ijms19051474

mTOR Signaling and Neural Stem Cells: The Tuberous Sclerosis Complex Model

1
Department of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
2
Institute for Molecular Cell Biology, University of Münster, Schlossplatz 5, 48149 Münster, Germany
3
Cells-in-Motion Cluster of Excellence, University of Münster, 48149 Münster, Germany
*
Author to whom correspondence should be addressed.
Received: 10 April 2018 / Revised: 4 May 2018 / Accepted: 11 May 2018 / Published: 16 May 2018
(This article belongs to the Special Issue Cell Growth Regulation)
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Abstract

The mechanistic target of rapamycin (mTOR), a serine-threonine kinase, plays a pivotal role in regulating cell growth and proliferation. Notably, a great deal of evidence indicates that mTOR signaling is also crucial in controlling proliferation and differentiation of several stem cell compartments. Consequently, dysregulation of the mTOR pathway is often associated with a variety of disease, such as cancer and metabolic and genetic disorders. For instance, hyperactivation of mTORC1 in neural stem cells (NSCs) is associated with the insurgence of neurological manifestation characterizing tuberous sclerosis complex (TSC). In this review, we survey the recent contributions of TSC physiopathology studies to understand the role of mTOR signaling in both neurogenesis and tumorigenesis and discuss how these new insights can contribute to developing new therapeutic strategies for neurological diseases and cancer. View Full-Text
Keywords: mTOR signaling; neural stem cells; tuberous sclerosis complex mTOR signaling; neural stem cells; tuberous sclerosis complex
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Polchi, A.; Magini, A.; Meo, D.D.; Tancini, B.; Emiliani, C. mTOR Signaling and Neural Stem Cells: The Tuberous Sclerosis Complex Model. Int. J. Mol. Sci. 2018, 19, 1474.

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