Next Article in Journal
Spatiotemporal Labeling of Melanocytes in Mice
Previous Article in Journal
Circulating MicroRNAs in Young Patients with Acute Coronary Syndrome
Previous Article in Special Issue
Peripheral B-Cell Subset Distribution in Primary Antiphospholipid Syndrome
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2018, 19(5), 1468; https://doi.org/10.3390/ijms19051468

Immunomodulatory Function of Myeloid-Derived Suppressor Cells during B Cell-Mediated Immune Responses

School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 6 April 2018 / Revised: 3 May 2018 / Accepted: 12 May 2018 / Published: 15 May 2018
(This article belongs to the Special Issue B Cells and Immunological Tolerance)
View Full-Text   |   Download PDF [1959 KB, uploaded 15 May 2018]   |  

Abstract

Myeloid-derived suppressor cells (MDSCs) play roles in immune regulation during neoplastic and non-neoplastic inflammatory responses. This immune regulatory function is directed mainly toward T cells. However, MDSCs also regulate other cell populations, including B cells, during inflammatory responses. Indeed, B cells are essential for antibody-mediated immune responses. MDSCs regulate B cell immune responses directly via expression of effector molecules and indirectly by controlling other immune regulatory cells. B cell-mediated immune responses are a major component of the overall immune response; thus, MDSCs play a prominent role in their regulation. Here, we review the current knowledge about MDSC-mediated regulation of B cell responses. View Full-Text
Keywords: MDSCs; B cells; inflammation; M-MDSCs; PMN-MDSCs MDSCs; B cells; inflammation; M-MDSCs; PMN-MDSCs
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Özkan, B.; Lim, H.; Park, S.-G. Immunomodulatory Function of Myeloid-Derived Suppressor Cells during B Cell-Mediated Immune Responses. Int. J. Mol. Sci. 2018, 19, 1468.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top