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Int. J. Mol. Sci. 2018, 19(5), 1451; https://doi.org/10.3390/ijms19051451

SOX7 Target Genes and Their Contribution to Its Tumor Suppressive Function

1
College of Life Science, Northeast Forestry University, Harbin 150040, Heilongjiang, China
2
Division of Math and Science, North Carolina Wesleyan College, Rocky Mount, NC 27804, USA
3
Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 19 March 2018 / Revised: 7 May 2018 / Accepted: 10 May 2018 / Published: 14 May 2018
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

SOX7 is a transcription factor and acts as a tumor suppressor, but its target genes in cancers are poorly explored. We revealed SOX7-mediated gene expression profile in breast cancer cells using microarray chips and discovered multiple altered signaling pathways. When combinatorially analyzing the microarray data with a gene array dataset from 759 breast cancer patients, we identified four genes as potential targets of SOX7 and validated them by quantitative PCR and chromatin immunoprecipitation assays. Among these four genes, we determined that SOX7-activated SPRY1 and SLIT2, and SOX7-repressed TRIB3 and MTHFD2 could all differentially contribute to SOX7-mediated tumor suppression. Overall, we identified multiple cancer-related pathways mediated by SOX7 and for the first time revealed SOX7-regulated target genes in a cancer-relevant context. View Full-Text
Keywords: SOX7; gene expression array; breast cancer; target genes; cell proliferation SOX7; gene expression array; breast cancer; target genes; cell proliferation
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Zhang, Y.; Stovall, D.B.; Wan, M.; Zhang, Q.; Chou, J.W.; Li, D.; Sui, G. SOX7 Target Genes and Their Contribution to Its Tumor Suppressive Function. Int. J. Mol. Sci. 2018, 19, 1451.

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