Irradiation-Induced Cardiac Connexin-43 and miR-21 Responses Are Hampered by Treatment with Atorvastatin and Aspirin
Abstract
:1. Introduction
2. Results
2.1. Main Characteristics of Experimental Rats
2.2. Protein Expression of Myocardial Cx43 in Control and Irradiated Wistar Rats
2.3. Expression of Protein Kinase Cε in Control and Irradiated Wistar Rats
2.4. Expression of Protein Kinase C δ in Control and Irradiated Wistar Rats
2.5. Myocardial Expression of miR-1 in Control and Irradiated Wistar Rats
2.6. Expression of miR-21 in Control and Irradiated Wistar Rats
3. Discussion
4. Materials and Methods
4.1. Experimental Model of Irradiation Induced Cardiac Injury
4.2. Determination of Myocardial Cx43, PKCε and PKCδ Protein Expression
4.3. Estimation of Myocardial miR-1 and miR-21 Levels
4.4. Statistical Analysis
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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GROUP | BW (g) | HW (g) | LVW (g) | RVW (g) |
---|---|---|---|---|
C | 344.22 ± 28.40 | 0.89 ± 0.11 | 0.36 ± 0.07 | 0.09 ± 0.02 |
C-A | 382.61 ± 32.19 | 0.92 ± 0.09 | 0.39 ± 0.04 | 0.12 ± 0.01 |
C-AT | 371.01 ± 20.45 | 0.87 ± 0.07 | 0.37 ± 0.04 | 0.10 ± 0.02 |
C-S | 363.63 ± 23.93 | 0.90 ± 0.10 | 0.39 ± 0.04 | 0.11 ± 0.02 |
I | 252.24 ± 14.31 a | 0.83 ± 0.05 | 0.25 ± 0.04 a | 0.10 ± 0.04 |
I-A | 227.41 ± 26.47 c | 0.73 ± 0.09 c | 0.24 ± 0.02 c | 0.11 ± 0.03 |
I-AT | 253.23 ± 31.82 c | 0.77 ± 0.08 | 0.27 ± 0.03 c | 0.13 ± 0.03 |
I-S | 233.62 ± 14.50 c | 0.67 ± 0.05 b,c | 0.23 ± 0.02 c | 0.12 ± 0.03 |
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Viczenczova, C.; Kura, B.; Egan Benova, T.; Yin, C.; Kukreja, R.C.; Slezak, J.; Tribulova, N.; Szeiffova Bacova, B. Irradiation-Induced Cardiac Connexin-43 and miR-21 Responses Are Hampered by Treatment with Atorvastatin and Aspirin. Int. J. Mol. Sci. 2018, 19, 1128. https://doi.org/10.3390/ijms19041128
Viczenczova C, Kura B, Egan Benova T, Yin C, Kukreja RC, Slezak J, Tribulova N, Szeiffova Bacova B. Irradiation-Induced Cardiac Connexin-43 and miR-21 Responses Are Hampered by Treatment with Atorvastatin and Aspirin. International Journal of Molecular Sciences. 2018; 19(4):1128. https://doi.org/10.3390/ijms19041128
Chicago/Turabian StyleViczenczova, Csilla, Branislav Kura, Tamara Egan Benova, Chang Yin, Rakesh C. Kukreja, Jan Slezak, Narcis Tribulova, and Barbara Szeiffova Bacova. 2018. "Irradiation-Induced Cardiac Connexin-43 and miR-21 Responses Are Hampered by Treatment with Atorvastatin and Aspirin" International Journal of Molecular Sciences 19, no. 4: 1128. https://doi.org/10.3390/ijms19041128