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Int. J. Mol. Sci. 2018, 19(3), 919; https://doi.org/10.3390/ijms19030919

Therapeutic Properties and Biological Benefits of Marine-Derived Anticancer Peptides

1
Department of Biomedical Science, Chosun University, Gwangju 501-759, Korea
2
Department of Bioinformatics, Kongju National University, Kongju 314-701, Korea
3
Research Center for Proteineous Materials, Chosun University, Gwangju 501-759, Korea
*
Author to whom correspondence should be addressed.
Received: 26 January 2018 / Revised: 7 March 2018 / Accepted: 16 March 2018 / Published: 20 March 2018
(This article belongs to the Special Issue Natural Bioactives and Phytochemicals in Cancer Prevention)

Abstract

Various organisms exist in the oceanic environment. These marine organisms provide an abundant source of potential medicines. Many marine peptides possess anticancer properties, some of which have been evaluated for treatment of human cancer in clinical trials. Marine anticancer peptides kill cancer cells through different mechanisms, such as apoptosis, disruption of the tubulin-microtubule balance, and inhibition of angiogenesis. Traditional chemotherapeutic agents have side effects and depress immune responses. Thus, the research and development of novel anticancer peptides with low toxicity to normal human cells and mechanisms of action capable of avoiding multi-drug resistance may provide a new method for anticancer treatment. This review provides useful information on the potential of marine anticancer peptides for human therapy. View Full-Text
Keywords: peptide; anticancer; marine organism; antiproliferative; therapeutic agents peptide; anticancer; marine organism; antiproliferative; therapeutic agents
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Kang, H.K.; Choi, M.-C.; Seo, C.H.; Park, Y. Therapeutic Properties and Biological Benefits of Marine-Derived Anticancer Peptides. Int. J. Mol. Sci. 2018, 19, 919.

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