The Modulatory Roles of N-glycans in T-Cell-Mediated Autoimmune Diseases
AbstractGlycosylation is a ubiquitous posttranslational modification of proteins that occurs in the endoplasmic reticulum/Golgi. N-glycans and mucin-type O-glycans are achieved via a series of glycohydrolase- and glycosyltransferase-mediated reactions. Glycosylation modulates immune responses by regulating thymocyte development and T helper cell differentiation. Autoimmune diseases result from an abnormal immune response by self-antigens and subsequently lead to the destruction of the target tissues. The modification of N-glycans has been studied in several animal models of T-cell-mediated autoimmune diseases. This review summarizes and highlights the modulatory effects of N-glycosylation in several autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, inflammatory bowel disease, and type 1 diabetes mellitus. View Full-Text
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Chien, M.-W.; Fu, S.-H.; Hsu, C.-Y.; Liu, Y.-W.; Sytwu, H.-K. The Modulatory Roles of N-glycans in T-Cell-Mediated Autoimmune Diseases. Int. J. Mol. Sci. 2018, 19, 780.
Chien M-W, Fu S-H, Hsu C-Y, Liu Y-W, Sytwu H-K. The Modulatory Roles of N-glycans in T-Cell-Mediated Autoimmune Diseases. International Journal of Molecular Sciences. 2018; 19(3):780.Chicago/Turabian Style
Chien, Ming-Wei; Fu, Shin-Huei; Hsu, Chao-Yuan; Liu, Yu-Wen; Sytwu, Huey-Kang. 2018. "The Modulatory Roles of N-glycans in T-Cell-Mediated Autoimmune Diseases." Int. J. Mol. Sci. 19, no. 3: 780.
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