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Int. J. Mol. Sci. 2018, 19(3), 776; https://doi.org/10.3390/ijms19030776

Emerging Roles of p53 Family Members in Glucose Metabolism

Cancer and Stem Cell Biology Program, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore
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Received: 19 January 2018 / Revised: 14 February 2018 / Accepted: 22 February 2018 / Published: 8 March 2018
(This article belongs to the Special Issue Emerging Non-Canonical Functions and Regulation of p53)
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Abstract

Glucose is the key source for most organisms to provide energy, as well as the key source for metabolites to generate building blocks in cells. The deregulation of glucose homeostasis occurs in various diseases, including the enhanced aerobic glycolysis that is observed in cancers, and insulin resistance in diabetes. Although p53 is thought to suppress tumorigenesis primarily by inducing cell cycle arrest, apoptosis, and senescence in response to stress, the non-canonical functions of p53 in cellular energy homeostasis and metabolism are also emerging as critical factors for tumor suppression. Increasing evidence suggests that p53 plays a significant role in regulating glucose homeostasis. Furthermore, the p53 family members p63 and p73, as well as gain-of-function p53 mutants, are also involved in glucose metabolism. Indeed, how this protein family regulates cellular energy levels is complicated and difficult to disentangle. This review discusses the roles of the p53 family in multiple metabolic processes, such as glycolysis, gluconeogenesis, aerobic respiration, and autophagy. We also discuss how the dysregulation of the p53 family in these processes leads to diseases such as cancer and diabetes. Elucidating the complexities of the p53 family members in glucose homeostasis will improve our understanding of these diseases. View Full-Text
Keywords: p53; p63; p73; p53 mutant; glucose metabolism; glycolysis; mitochondria; autophagy; diabetes; cancer p53; p63; p73; p53 mutant; glucose metabolism; glycolysis; mitochondria; autophagy; diabetes; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Itahana, Y.; Itahana, K. Emerging Roles of p53 Family Members in Glucose Metabolism. Int. J. Mol. Sci. 2018, 19, 776.

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