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Int. J. Mol. Sci. 2018, 19(3), 674; doi:10.3390/ijms19030674

Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis

Rheumatology Division, Department of Internal Medicine, Hallym University Sacred Heart Hospital, 896, Pyongchondong, Dongan-gu, Anyang, Kyunggi-do 431-070, Korea
Department of Internal Medicine, Kangdong Sacred Heart Hospital, Seoul 05355, Korea
These authors contributed equally to work.
Author to whom correspondence should be addressed.
Received: 11 January 2018 / Revised: 14 February 2018 / Accepted: 21 February 2018 / Published: 27 February 2018
(This article belongs to the Special Issue Research of Pathogenesis and Novel Therapeutics in Arthritis)
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Osteoarthritis (OA) is the most prevalent joint disease in older people and is characterized by the progressive destruction of articular cartilage, synovial inflammation, changes in subchondral bone and peri-articular muscle, and pain. Because our understanding of the aetiopathogenesis of OA remains incomplete, we haven’t discovered a cure for OA yet. This review appraises novel therapeutics based on recent progress in our understanding of the molecular pathogenesis of OA, including pro-inflammatory and pro-catabolic mediators and the relevant signalling mechanisms. The changes in subchondral bone and peri-articular muscle accompanying cartilage damage are also reviewed. View Full-Text
Keywords: osteoarthritis (OA); articular cartilage; molecular pathology; therapeutics osteoarthritis (OA); articular cartilage; molecular pathology; therapeutics

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kim, J.-R.; Yoo, J.J.; Kim, H.A. Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis. Int. J. Mol. Sci. 2018, 19, 674.

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