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Int. J. Mol. Sci. 2018, 19(3), 664; doi:10.3390/ijms19030664

Magnesium Replacement to Protect Cardiovascular and Kidney Damage? Lack of Prospective Clinical Trials

Nephrology Service, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University Hospital Reina Sofía, University of Córdoba, 14004 Córdoba, Spain
Red de Investigación Renal (REDinREN), Instituto de Salud Carlos III, 28029 Madrid, Spain
Both authors share first authorship.
Author to whom correspondence should be addressed.
Received: 9 January 2018 / Revised: 12 February 2018 / Accepted: 21 February 2018 / Published: 27 February 2018
(This article belongs to the Section Molecular Toxicology)
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Patients with advanced chronic kidney disease exhibit an increase in cardiovascular mortality. Recent works have shown that low levels of magnesium are associated with increased cardiovascular and all-cause mortality in hemodialysis patients. Epidemiological studies suggest an influence of low levels of magnesium on the occurrence of cardiovascular disease, which is also observed in the normal population. Magnesium is involved in critical cellular events such as apoptosis and oxidative stress. It also participates in a number of enzymatic reactions. In animal models of uremia, dietary supplementation of magnesium reduces vascular calcifications and mortality; in vitro, an increase of magnesium concentration decreases osteogenic transdifferentiation of vascular smooth muscle cells. Therefore, it may be appropriate to evaluate whether magnesium replacement should be administered in an attempt to reduce vascular damage and mortality in the uremic population In the present manuscript, we will review the magnesium homeostasis, the involvement of magnesium in enzymatic reactions, apoptosis and oxidative stress and the clinical association between magnesium and cardiovascular disease in the general population and in the context of chronic kidney disease. We will also analyze the role of magnesium on kidney function. Finally, the experimental evidence of the beneficial effects of magnesium replacement in chronic kidney disease will be thoroughly described. View Full-Text
Keywords: magnesium; chronic kidney disease; cardiovascular disease; vascular calcification; mortality magnesium; chronic kidney disease; cardiovascular disease; vascular calcification; mortality

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Muñoz-Castañeda, J.R.; Pendón-Ruiz de Mier, M.V.; Rodríguez, M.; Rodríguez-Ortiz, M.E. Magnesium Replacement to Protect Cardiovascular and Kidney Damage? Lack of Prospective Clinical Trials. Int. J. Mol. Sci. 2018, 19, 664.

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