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Int. J. Mol. Sci. 2018, 19(3), 652; doi:10.3390/ijms19030652

Regulation of Cell Signaling Pathways and miRNAs by Resveratrol in Different Cancers

Institute of Biomedical and Genetic Engineering (IBGE), Islamabad 44000, Pakistan
Department of Bioinformatics and Biotechnology, International Islamic University, Islamabad 44000, Pakistan
Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA
Author to whom correspondence should be addressed.
Received: 28 January 2018 / Revised: 8 February 2018 / Accepted: 25 February 2018 / Published: 26 February 2018
(This article belongs to the Special Issue Bioactive Phenolics and Polyphenols 2018)
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Genomic and proteomic studies have helped improve our understanding of the underlying mechanism(s) of cancer development and progression. Mutations, overexpressed oncogenes, inactivated/downregulated tumor suppressors, loss of apoptosis, and dysregulated signal transduction cascades are some of the well-studied areas of research. Resveratrol has gained considerable attention in the last two decades because of its pleiotropic anticancer activities. In this review, we have summarized the regulation of WNT, SHH (sonic hedgehog)/GLI (glioma-associated oncogene homolog), TGFβ1 (transforming growth factor beta 1)/SMAD, NOTCH, TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), STAT (signal transducer and activator of transcription), and microRNAs by resveratrol in different cancers. The importance of these signaling pathways in cancer progression, along with their modulation by resveratrol, is discussed. Further, we also evaluate the mechanisms and implications of the downregulation of oncogenic miRNAs and the upregulation of tumor suppressor miRNAs by resveratrol, both of which also define its ability to inhibit tumor growth and metastasis. It is envisioned that designing effective clinical trials will be helpful for the identification of resveratrol responders and non-responders and the elucidation of how this phytochemical can be combined with current therapeutic options to improve their clinical efficacy and reduce off-target effects. View Full-Text
Keywords: resveratrol; cell signaling; miRNAs resveratrol; cell signaling; miRNAs

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Farooqi, A.A.; Khalid, S.; Ahmad, A. Regulation of Cell Signaling Pathways and miRNAs by Resveratrol in Different Cancers. Int. J. Mol. Sci. 2018, 19, 652.

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